TAILIEUCHUNG - Báo cáo y học: "Genetic control of disease in an experimental model for Sjögren’s syndrome Åsa Andersson"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Genetic control of disease in an experimental model for Sjögren’s syndrome Åsa Andersson. | Available online http content 11 1 102 Editorial Genetic control of disease in an experimental model for Sjogren s syndrome Ảsa Andersson Department of Pharmacology and Pharmacotherapy Faculty of Pharmaceutical Sciences Copenhagen University Universitetsparken 2 DK-2100 Copenhagen 0 Denmark Corresponding author Ảsa Andersson aaa@ Published 20 January 2009 Arthritis Research Therapy 2009 11 102 doi ar2583 This article is online at http content 11 1 102 2009 BioMed Central Ltd See related research by Nguyen et al. http content 10 6 R137 Abstract Sjogren s syndrome is an autoimmune disease with a complex etiology depending on hereditary and environmental factors. The disease is characterized by lymphocytic infiltration and inflammation in the salivary and lacrimal glands leading to oral and ocular dryness. To understand the genetic susceptibility in Sjogren s syndrome studies of disease phenotypes have been performed in the non-obese diabetic NOD mouse. By the identification of genetic regions controlling development of autoimmune exocrino-pathy in the NOD mouse and by reducing one of these regions considerably Nguyen et al. in a recent issue of Arthritis Research and Therapy propose candidate genes for development of Sjogren s syndrome. Susceptibility to autoimmune diseases is dependent on multiple genes of which most contribute minor effects that precipitate the disease when expressed in the right environmental context. The rationale behind studies of genetics in complex diseases is that identification of gene variants contributing to susceptibility will provide important information concerning the pathogenesis and hopes for future therapy. Experimental animal models are used to address hereditary factors of complex human diseases. The genetics and the environment can be carefully controlled in such models and the number of siblings is high enough to allow for the identification

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.