TAILIEUCHUNG - Báo cáo y học: "Osteoimmunology in rheumatic diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Osteoimmunology in rheumatic diseases. | Available online http content 11 1 210 Review Osteoimmunology in rheumatic diseases Georg Schett Department of Internal Medicine 3 and Institute for Clinical Immunology University of Erlangen-Nuremberg Erlangen Germany Corresponding author Georg Schett Published 30 January 2009 This article is online at http content 11 1 210 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 210 doi ar2571 Abstract This review summarizes the recent advances of osteoimmunology a new research field that investigates the interaction of the immune system with the skeleton. Osteoimmunology has contributed significantly to the understanding of joint destruction in rheumatoid arthritis and other forms of arthropathies. In particular the molecular regulation of osteoclast formation and its control by proinflammatory cytokines have helped investigators to understand the mechanisms of bone erosion in rheumatic diseases. Osteoimmunology has also allowed an improvement in our knowledge of the structure-sparing effects of antirheumatic drug therapy. Moreover recent advances in the understanding of the molecular regulation of osteophyte formation are based on the characterization of the regulation of bone formation by inflammation. This review highlights the key insights into the regulation of bone destruction and formation in arthritis. Moreover concepts of how bone influences the immune system are discussed. Introduction Two major aspects determine the clinical picture of rheumatic diseases. The first one is that inflammation is considered a central component of many especially the most severe forms of rheumatic diseases. Based on the observation of autoantibody formation and the accumulation of cells of the adaptive immune system at sites of inflammation some rheumatic diseases such as rheumatoid arthritis RA systemic lupus erythematosus or Sjogren syndrome are considered to be classic systemic .

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