TAILIEUCHUNG - Báo cáo y học: "What do biomarkers tell us about the pathogenesis of ankylosing spondylitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: What do biomarkers tell us about the pathogenesis of ankylosing spondylitis? | Available online http content 11 1 101 Editorial What do biomarkers tell us about the pathogenesis of ankylosing spondylitis Walter P Maksymowych Department of Medicine University of Alberta Edmonton Alberta T6G 2S2 Canada Corresponding author Walter P Maksymowych See related research article by Appel et al. http content 10 5 R125 Published 7 January 2009 This article is online at http content 11 1 101 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 101 doi ar2565 Abstract Biomarkers may provide information that promotes understanding of prognosis disease activity and pathogenesis in ankylosing spondylitis. Biomarkers reflecting disease activity metalloproteinase-3 and inflammatory lesions on magnetic resonance imaging predict new bone formation and are ameliorated by antitumor necrosis factor therapy yet this treatment may not prevent new bone formation. Moreover elevated levels of biomarkers reflecting tissue repair bone-specific alkaline phosphatase posttreatment together with magnetic resonance imaging indicates such treatment may even promote repair through new bone formation. Tumor necrosis factor regulation of Dickkopf-1 may constitute a molecular brake that controls osteoblastogenesis through wingless and bone morphogenetic proteins in an established inflammatory lesion in ankylosing spondylitis. Appel and colleagues 1 have studied the link between inflammation destruction and repair in ankylosing spondylitis AS by analyzing serological biomarkers thought to reflect these processes. How does this advance our understanding and assessment of AS First biomarkers may provide information that is of prognostic value particularly if sufficiently validated to be considered surrogates for structural damage end points. This constitutes a major priority for investigation in AS because of the generally slow rate of progression of radiographic change 2

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