TAILIEUCHUNG - Báo cáo y học: "Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease. | Available online http content 5 1 25 Commentary COX-2 where are we in 2003 Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease Leslie J Crofford Associate Professor of Internal Medicine Division of Rheumatology University of Michigan Ann Arbor Michigan USA Corresponding author Leslie J Crofford e-mail crofford@ Received 5 November 2002 Accepted 19 November 2002 Published 9 December 2002 Arthritis Res Ther 2003 5 25-27 DOI ar620 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 See related commentaries pages 5 8 and 28 Abstract The use of analgesic anti-inflammatory agents in patients with asthma is clinically challenging because of the prevalence 10-20 of aspirin hypersensitivity. Aspirin-exacerbated respiratory disease AERD or aspirin-induced asthma is characterized by asthma and rhinitis triggered by the ingestion of aspirin and non-steroidal anti-inflammatory drugs. AERD is associated with upper and lower respiratory-tract mucosal inflammation progressive sinusitis nasal polyposis and asthma regardless of whether patients avoid triggering drugs. The mechanism underlying the propensity of aspirin and nonsteroidal anti-inflammatory drugs to cause this reaction is thought to involve inhibition of the synthesis of protective prostaglandins PGs resulting in an increase in the synthesis of cysteinyl leukotrienes by eosinophils and mast cells. Clinical data suggest that protective PGs are derived from cyclooxygenase COX -1 because studies have now confirmed that drugs specifically inhibiting COX-2 are not crossreactive with aspirin in patients with AERD. Keywords aspirin asthma cyclooxygenase inhibitors non-steroidal anti-inflammatory drugs Introduction Up to 10-20 of the general asthmatic population have hypersensitivity to aspirin and non-steroidal anti-inflammatory drugs NSAIDs leading to severe exacerbation of asthma and naso-ocular reactions 1 2 . Formerly termed .

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