TAILIEUCHUNG - báo cáo hóa học:" Elevated osteoprotegerin is associated with abnormal ankle brachial indices in patients infected with HIV: a cross-sectional study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Elevated osteoprotegerin is associated with abnormal ankle brachial indices in patients infected with HIV: a cross-sectional study | Jang et al. Journal of the International AIDS Society 2010 13 12 http content 13 1 12 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Elevated osteoprotegerin is associated with abnormal ankle brachial indices in patients infected with HIV a cross-sectional study 1 1 1 2 1 3 James J Jang Aron I Schwarcz Daniel A Amaez Mark Woodward Jeffrey W Olin Marla J Keller Alison D Schecter1 Abstract Background Patients infected with HIV have an increased risk for accelerated atherosclerosis. Elevated levels of osteoprotegerin an inflammatory cytokine receptor have been associated with a high incidence of cardiovascular disease including peripheral arterial disease or PAD acute coronary syndrome and cardiovascular mortality. The objective of this study was to determine whether PAD is prevalent in an HIV-infected population and to identify an association with HIV-specific and traditional cardiovascular risk factors as well as levels of osteoprotegerin. Methods One hundred and two patients infected with HIV were recruited in a cross-sectional study. To identify the prevalence of PAD ankle-brachial indices ABIs were measured. Four standard ABI categories were utilized definite PAD borderline normal and high . Medical history and laboratory measurements were obtained to determine possible risk factors associated with PAD in HIV-infected patients. Results The prevalence of PAD ABI in a young HIV-infected population mean age 48 years was 11 . Traditional cardiovascular risk factors including advanced age and previous cardiovascular history as well as elevated C-reactive protein levels were associated with PAD. Compared with patients with normal ABIs patients with high ABIs had significantly elevated levels of osteoprotegerin pg ml vs. pg ml respectively p . Conclusions There is a high prevalence of PAD in young HIV-infected patients. A number of traditional cardiovascular risk factors

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