TAILIEUCHUNG - báo cáo hóa học:" High survival and treatment success sustained after two and three years of first-line ART for children in Cambodia"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : High survival and treatment success sustained after two and three years of first-line ART for children in Cambodia | Isaakidis et al. Journal of the International AIDS Society 2010 13 11 http content 13 1 11 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access High survival and treatment success sustained after two and three years of first-line ART for children in Cambodia Petros Isaakidis 1 Marie-Eve Raguenaud1 Vantha Te2 Chhraing S Tray3 Kazumi Akao3 Varun Kumar3 Sopheak Ngin4 Eric Nerrienet4 Rony Zachariah5 Abstract Background Long-term outcomes of antiretroviral therapy ART in children remain poorly documented in resource-limited settings. The objective of this study was to assess two-and three-year survival CD4 evolution and virological response among children on ART in a programmatic setting in Cambodia. Methods Children treated with first-line ART for at least 24 months were assessed with viral load testing and genotyping. We used Kaplan-Meier analysis for survival and Cox regression to identify risk factors associated with treatment failure. Results Of 1168 registered HIV-positive children 670 57 started ART between January 2003 and December 2007. Survival probability was 95 CI and 95 CI at 24 and 36 months after ART initiation respectively. Median CD4 gain for children aged over five years was 704 cells mm3 at 24 months and 737 at 36 months. Median CD4 percentage gain for children under five years old was at 24 months and 15 at 36 months. One hundred and thirty children completed at least 24 months of ART and 138 completed 36 months 128 out of 268 48 were female. Median age at ART initiation was six years. Overall 22 children had viral loads of 1000 copies ml success ratio 86 on intention-to-treat-analysis and 21 of 21 presented mutations conferring resistance mostly to lamivudine and non-nucleoside reverse transcriptase inhibitors. Risk factors for failure after 24 and 36 months were CD4 counts below the threshold for severe immuno-supression at those months respectively. Only two out of 22 children with .

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