TAILIEUCHUNG - báo cáo hóa học:" Couples’ voluntary counselling and testing and nevirapine use in antenatal clinics in two African capitals: a prospective cohort study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Couples’ voluntary counselling and testing and nevirapine use in antenatal clinics in two African capitals: a prospective cohort study | Conkling et al. Journal of the International AIDS Society 2010 13 10 http content 13 1 10 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Couples voluntary counselling and testing and nevirapine use in antenatal clinics in two African capitals a prospective cohort study Martha Conkling1 2 Erin L Shutes1 2 Etienne Karita1 2 Elwyn Chomba1 2 3 Amanda Tichacek1 2 Moses Sinkala4 Bellington Vwalika1 2 3 Melissa Iwanowski5 Susan A Allen1 2 Abstract Background With the accessibility of prevention of mother to child transmission PMTCT services in sub-Saharan Africa more women are being tested for HIV in antenatal care settings. Involving partners in the counselling and testing process could help prevent horizontal and vertical transmission of HIV. This study was conducted to assess the feasibility of couples voluntary counseling and testing CVCT in antenatal care and to measure compliance with PMTCT. Methods A prospective cohort study was conducted over eight months at two public antenatal clinics in Kigali Rwanda and Lusaka Zambia. A convenience sample of 3625 pregnant women was enrolled. Of these 1054 women were lost to follow up. The intervention consisted of same-day individual voluntary counselling and testing VCT and weekend CVCT HIV-positive participants received nevirapine tablets. In Kigali nevirapine syrup was provided in the labour and delivery ward in Lusaka nevirapine syrup was supplied in pre-measured single-dose syringes. The main outcome measures were nurse midwife-recorded deliveries and reported nevirapine use. Results In eight months 1940 women enrolled in Kigali 984 VCT 956 CVCT and 1685 women enrolled in Lusaka 1022 VCT 663 CVCT . HIV prevalence was 14 in Kigali and 27 in Lusaka. Loss to follow up was more common in Kigali than Lusaka 33 vs. 24 p . In Lusaka HIV-positive and HIV-negative women had significantly different loss-to-follow-up rates 30 vs. 22 p . CVCT was associated with reduced loss to follow up

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