TAILIEUCHUNG - báo cáo hóa học:" Cytokine Profiles in Human Immunodeficiency Virus-Infected Children Treated With Highly Active "

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Cytokine Profiles in Human Immunodeficiency Virus-Infected Children Treated With Highly Active | Journal of the International AIDS Society BioMed Central Research Cytokine Profiles in Human Immunodeficiency Virus-Infected Children Treated With Highly Active Antiretroviral Therapy Brian M Jones 1 Susan SS Chiu2 Wilfred HS Wong3 Wilina WL Lim4 and Yu-lung Lau5 Address 1Head of Division of Clinical Immunology Department of Pathology University of Hong Kong Hong Kong PR China 2Associate Professor Department of Pediatrics and Adolescent Medicine University of Hong Kong Hong Kong PR China 3Senior Technician Department of Pediatrics and Adolescent Medicine University of Hong Kong Hong Kong PR China 4Head of Unit Government Virus Unit Department of Health Hong Kong PR China and 5Professor and Chair Department of Pediatrics and Adolescent Medicine University of Hong Kong Hong Kong PR China Email Brian M Jones - bmjones@ Corresponding author Open Access Published 3 May 2005 Journal of the International AIDS Society 2005 7 71 This article is available from http content 7 2 7l Abstract Context There have been few longitudinal studies of cytokine production in neonatally acquired HIV-1 infection and none in Asian or Chinese children. Objective To determine whether monitoring cytokine production could contribute to the better management of pediatric patients with HIV-1 infection. Setting Clinical Immunology Laboratory and Pediatrics Department University Hospital Hong Kong. Patients Ten Asian and 2 Eurasian children infected with HIV-1 by mother-to-child transmission were followed for up to 5 years while on treatment with highly active antiretroviral therapy HAART . Main Outcome Measures Numbers of unstimulated and mitogen-activated cytokine-secreting cells IFN-gamma interleukin IL -2 IL-4 IL-6 IL-10 IL-12 and TNF-alpha were measured by ELISPOT assay at frequent intervals and correlations were sought with CD4 and CD8 cell counts and viral loads. Results Mitogen-stimulated IL-2-secreting cells were directly associated with recovery of CD4 cells. .

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