TAILIEUCHUNG - báo cáo hóa học:" Luteal blood flow in patients undergoing GnRH agonist long protocol"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Luteal blood flow in patients undergoing GnRH agonist long protocol | Takasaki et al. Journal of Ovarian Research 2011 4 2 http content 4 1 2 RESEARCH JOURNAL OF OVARIAN RESEARCH Open Access Luteal blood flow in patients undergoing GnRH agonist long protocol Akihisa Takasaki2 Isao Tamura1 Fumie Kizuka1 Lifa Lee1 Ryo Maekawa1 Hiromi Asada1 Toshiaki Taketani1 Hiroshi Tamura1 Katsunori Shimamura2 Hitoshi Morioka2 Norihiro Sugino1 Abstract Background Blood flow in the corpus luteum CL is closely related to luteal function. It is unclear how luteal blood flow is regulated. Standardized ovarian-stimulation protocol with a gonadotropin-releasing hormone agonist GnRHa long protocol causes luteal phase defect because it drastically suppresses serum LH levels. Examining luteal blood flow in the patient undergoing GnRHa long protocol may be useful to know whether luteal blood flow is regulated by LH. Methods Twenty-four infertile women undergoing GnRHa long protocol were divided into 3 groups dependent on luteal supports 9 women were given ethinylestradiol plus norgestrel Planovar orally throughout the luteal phase control group 8 women were given HCG 2 000 IU on days 2 and 4 day after ovulation induction in addition to Planovar HCG group 7 women were given vitamin E 600 mg day orally throughout the luteal phase in addition to Planovar vitamin E group . Blood flow impedance was measured in each CL during the mid-luteal phase by transvaginal color-pulsed-Doppler-ultrasonography and was expressed as a CL-resistance index CL-RI . Results Serum LH levels were remarkably suppressed in all the groups. CL-RI in the control group was more than the cutoff value and only 2 out of 9 women had CL-RI values . Treatments with HCG or vitamin E significantly improved the CL-RI to less than . Seven of the 8 women in the HCG group and all of the women in the vitamin E group had CL-RI . Conclusion Patients undergoing GnRHa long protocol had high luteal blood flow impedance with very low serum LH levels. HCG administration

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