TAILIEUCHUNG - báo cáo hóa học:" Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study | Journal of Ovarian Research BioMed Central Open Access Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse a microarray study John Brannian 1 2 3 Kathleen Eyster1 2 Mandi Greenway4 Cody Henriksen4 Kim TeSlaa4 and Maureen Diggins4 Address Department of Obstetrics Gynecology Sanford School of Medicine University of South Dakota Sioux Falls SD 57105 USA 2Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota Vermillion SD USA 3Sanford Research USD Sioux Falls SD USA and 4Department of Biology Augustana College Sioux Falls SD USA Email John Brannian - jbrannia@ Kathleen Eyster - keyster@ Mandi Greenway - Cody Henriksen - clhenriksen@ Kim TeSlaa - kdteslaa@ Maureen Diggins - diggins@ Corresponding author Published 3 August 2009 Received 29 June 2009 Journal of Ovarian Research 2009 2 10 doi 1757-2215-2-10 Accepted 3 August 2009 This article is available from http content 2 1 10 2009 Brannian et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lethal yellow LY C57BL 6J Ay a mice exhibit adult-onset obesity altered metabolic regulation and early reproductive senescence. The present study was designed to test the hypothesis that obese LY mice possess differences in expression of ovarian genes relative to age-matched lean mice. Methods 90- and 180-day-old LY and lean black C57BL 6J a a mice were suppressed with GnRH antagonist Antide then stimulated with 5 IU eCG. cRNA derived from RNA extracts of whole ovarian homogenates collected 36 h post-eCG were run individually on Codelink Mouse Whole Genome Bioarrays GE Healthcare Life Sciences .

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