TAILIEUCHUNG - The HuGENet™ HuGE Review Handbook, version 1.0

To understand the role of the shaman, and to know anything of his genius in using plants, one must be prepared to accept the possibility that when he tells of moving into realms of the spirit, he is not speaking in metaphor. This was perhaps the most difficult lesson for me to learn as an ethnobotanist schooled in science. With the dexterity of a modern chemist, they recognized that the different compounds in relatively small concentrations might effectively potentiate one another. In the case of ayahuasca, some twenty-one mixtures have been identified, including most notably Psychotria viridis. “Now I ask. | The HuGENet HuGE Review Handbook version Editors Julian Little6 Julian Higgins2 3 Writing group Molly Bray1 Julian Higgins2 3 John Ioannidis4 Muin Khoury5 Julian Little6 Teri Manolio7 Liam Smeeth8 Jonathan Sterne9 on behalf of the HuGE Net Systematic Review and Meta-Analysis Working Group Betsy Anagnostelis Adam Butterworth John Danesh Carol Dezateux Doug Easton John Gallacher Marta Gwinn Julian Higgins John Ioannidis Muin Khoury Sarah Lewis Julian Little Teri Manolio David Melzer Cosetta Minelli Paul Pharoah Georgia Salanti Simon Sanderson Liam Smeeth Lesley Smith Jonathan Sterne Donna Stroup Emanuela Taioli John Thompson Simon Thompson Neil Walker Ron Zimmern and HuGE Net Executive Group Molly Bray Marta Gwinn Julian Higgins John Ioannidis Muin Khoury Julian Little Teri Manolio Ron Zimmern 1USDA ARS Children s Nutrition Research Center Baylor College of Medicine Houston TX 77030 USA 2MRC Biostatistics Unit University of Cambridge Cambridge CB2 2SR UK 3Public Health Genetics Unit Strangeways Research Laboratory Cambridge CB1 8RN UK 4Clinical and Molecular Epidemiology Unit Department of Hygiene and Epidemiology University of Ioannina School of Medicine and Biomedical Research Institute Foundation for Research and Technology-Hellas Ioannina 45110 Greece 5Office of Genomics and Disease Prevention CDC Atlanta GA 30333 USA 6Canada Research Chair in Human Genome Epidemiology Department of Epidemiology and Community Medicine University of Ottawa Ottawa Ontario K1H 8M5 Canada National Human Genome Research Institute National Institutes of Health Bethesda USA Department of Epidemiology and Population Health London School of Hygiene and Tropical Medicine Keppel Street London WC1E 7HT UK Department of Social Medicine University of Bristol Canynge Hall Whiteladies Road Bristol BS8 2PR UK. CONTENTS CITATION FEEDBACK 1. INTRODUCTION 2. FORMAT FOR HuGE ASSOCIATION REVIEWS AND META-ANALYSES General format Potential conflicts of interest Publication of HuGE .

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