TAILIEUCHUNG - Báo cáo y học: "Nonimmunoglobulin E–Mediated Immune Reactions to Foods"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Nonimmunoglobulin E–Mediated Immune Reactions to Foods. | Review Article Nonimmunoglobulin E-Mediated Immune Reactions to Foods Jonathan M. Spergel MD PhD Abstract Adverse food reactions are abnormal responses to ingested foods. Reactions vary from immunologic to nonimmunologic immune reactions and can be either immunoglobulin E IgE mediated or non-IgE mediated. Food-induced IgE-mediated reactions range from localized urticaria to anaphylaxis and have been well studied. However in comparison there has been significantly less research into non-IgE-mediated food reactions. Non-IgE-mediated reactions can cause respiratory gastrointestinal and cutaneous symptoms. The most recent evidence suggests that these reactions are probably T-cell mediated as evidenced in lymphocyte proliferation assays. This review will explore the symptoms and testing methods of the most common non-IgE-mediated reactions. An adverse food reaction is any abnormal response to an ingested food regardless of the pathophysiology. One classification scheme separates immunologic from nonimmunologic entities. Non-immune reactions include jitteriness from caffeine and metabolic disorders such as lactase deficiency. Immune reactions are divided into those that are immunoglobulin E IgE -mediated and those that are not IgE mediated. IgE-mediated reactions are the classic presentations of food allergy such as hives or anaphylaxis after ingestion of the offending food antigen. Non-IgE-medi-ated food reactions have been described in the . Spergel Assistant Professor of Pediatrics Division of Allergy and Immunology Department of Pediatrics The Children s Hospital of Philadelphia University of Pennsylvania School of Medicine Philadelphia Pennsylvania Correspondence to Dr. Jonathan M. Spergel e-mail spergel@ DOI last several years and include food protein-induced enterocolitis syndrome and allergic eosinophilic esophagitis. Non-IgE-mediated food reactions are classified as negative skin test results or specific IgE to foods with

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