TAILIEUCHUNG - Cannabinoids in medicine: A review of their therapeutic potential

Semantic Web technologies enable the integration of heterogeneous data using expli- cit semantics, the expression of rich and well-defined models for data aggregation, and the application of logic to gain new knowledge from the raw data [12]. Semantic tech- nologies can be used to encode metadata such as provenance, . the original source where the data came from and how it was generated [13][14]. There are four main Semantic Web standards for knowledge representation: Resource Description Frame- work(RDF),RDFSchema(RDFS),WebOntologyLanguage(OWL),andSPARQL query language. Ontologies, which formalize the meaning of terms used in discourse, are expected to play a major role in the automated integration of patient data with relevant informa- tion to support. | Available online at Journal of ETHNO- PHARMACOLOGY ELSEVIER Journal of Ethnopharmacology 105 2006 1-25 locate jethpharm Review Cannabinoids in medicine A review of their therapeutic potential Mohamed Ben Amar Substance Abuse Program Faculties of Continuing Education and Graduate Studies University of Montreal . 6128 succursale Centre-ville Montreal Que. H3C 3J7 Canada Received 12 October 2005 received in revised form 30 January 2006 accepted 2 February 2006 Abstract In order to assess the current knowledge on the therapeutic potential of cannabinoids a meta-analysis was performed through Medline and PubMed up to July 1 2005. The key words used were cannabis marijuana marihuana hashish hashich haschich cannabinoids tetrahydrocannabinol THC dronabinol nabilone levonantradol randomised randomized double-blind simple blind placebo-controlled and human. The research also included the reports and reviews published in English French and Spanish. For the final selection only properly controlled clinical trials were retained thus open-label studies were excluded. Seventy-two controlled studies evaluating the therapeutic effects of cannabinoids were identified. For each clinical trial the country where the project was held the number of patients assessed the type of study and comparisons done the products and the dosages used their efficacy and their adverse effects are described. Cannabinoids present an interesting therapeutic potential as antiemetics appetite stimulants in debilitating diseases cancer and AIDS analgesics and in the treatment of multiple sclerosis spinal cord injuries Tourette s syndrome epilepsy and glaucoma. 2006 Elsevier Ireland Ltd. All rights reserved. Keywords Cannabinoids Cannabis Therapeutic potential Controlled clinical trials Efficacy Safety Contents 1. Introduction. 2 2. Methodology. 3 3. Results. 3 . Antiemetic effect. 3 . Appetite stimulation. 9 . Analgesia. 9 . Multiple sclerosis. 11 . .

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• Molecular Pathogenesis
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