TAILIEUCHUNG - Báo cáo y học: "Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome. | Int. J. Med. Sci. 2010 7 15 International Journal of Medical Sciences 2010 7 1 15-18 Ivyspring International Publisher. All rights reserved Research Paper Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome Hirohisa Okuma 1 H Yasuhisa Kitagawa 2 Takashi Yasuda 2 Kentaro Tokuoka 2 Shigeharu Takagi 3 1. Department of Neurology Tokai University Tokyo Hospital 2. Department of Neurology Tokai University Hachioji Hospital 3. Department of Neurology Tokai University School of Medicine. H Correspondence to Hirohisa Okuma Department of Neurology Tokai University Tokyo Hospital 1-2-5 Shibuya-ku Yoyogi Tokyo 151-0053 Japan. Tel 81-3-3370-2321 Fax 81-3-3370-2321 E-mail ookuma@ Received Accepted Published Abstract Satisfactory results have not yet been obtained in therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome APS . We therefore compared single antiplatelet therapy and a combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with APS. The subjects were 20 ischemic stroke patients with antiphospholipid antibody 1 3 with primary antiphospholipid syndrome and 7 with SLE-related antiphospholipid syndrome. Diagnosis of APS was based on the 2006 Sydney criteria. Eligible patients were randomly assigned to either single antiplatelet therapy aspirin 1 00 mg or a combination of antiplatelet and anticoagulation therapy target INR mean for the secondary prevention of stroke according to a double-blind protocol. There was no significant difference between the two groups in age gender NIH Stroke Scale on admission mRS at discharge or rate of hypertension diabetes mellitus hyperlipidemia or cardiac disease. We obtained Kaplan-Meier survival curves for each treatment. The primary outcome was .

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