TAILIEUCHUNG - Báo cáo y học: "Maternal use of Loratadine during pregnancy and risk of hypospadias in offspring"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Maternal use of Loratadine during pregnancy and risk of hypospadias in offspring. | Int. J. Med. Sci. 2006 3 21 International Journal of Medical Sciences ISSN 1449-1907 2006 3 1 21-25 2006 Ivyspring International Publisher. All rights reserved Research paper Maternal use of Loratadine during pregnancy and risk of hypospadias in offspring Lars Pedersen Mette Vinther Skriver Mette N0rgaard Henrik Toft S0rensen Department of Clinical Epidemiology Aarhus University Hospital Ole Worms Alle 1150 DK-8000 Aarhus C Denmark Corresponding address Lars Pedersen Department of Clinical Epidemiology Ole Worms Alle 1150 DK-8000 Aarhus C Denmark. Tel 45 8942 4805 Fax 45 8942 4801 E-mail lap@ Received Accepted Published To examine the risk of hypospadias after exposure to loratadine and other antihistamines during pregnancy we conducted a population-based case-control stUdy in four Danish counties which account for 30 of the Danish population M . We obtained data onmaternal useof antihistamines from prescription databases and data on birth outcomes from the Danish Medical Birth Registry MBR and the Hospital DischargeRegistry HDR . A total of 65 383 male births with a full prescription history ofthe mother in the study period from 1989-2002 were available for analysis. Within this cohort we identified cases with a diagnosis of hypospadias and 10 selected controls per case without such a diagnosis matched on birth month gender andyear of birth . We identified 227 cases of hypospadias recorded in the HDR within six months postpartum and 2270 controls. One case and eight controls were exposed to loratadine in the first trimester and up to 30 days before the time of conception. The adjusted odds ratio OR for hypospadias among users of loratadine relative to non-users was 95 CI and the corresponding OR for other antihistamines was 95 CI . In this study maternal exposure to loratadine did not appear to be associated with an increased risk of hypospadias when compared with other .

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