TAILIEUCHUNG - Báo cáo toán học: "MAINTENANCE HORMONAL TREATMENT IMPROVES PROGRESSION FREE SURVIVAL AFTER A FIRST LINE CHEMOTHERAPY IN PATIENTS WITH METASTATIC BREAST CANCER"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: MAINTENANCE HORMONAL TREATMENT IMPROVES PROGRESSION FREE SURVIVAL AFTER A FIRST LINE CHEMOTHERAPY IN PATIENTS WITH METASTATIC BREAST CANCER. | Int. J. Med. Sci. 2008 5 100 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2008 5 2 100-105 Ivyspring International Publisher. All rights reserved MAINTENANCE HORMONAL TREATMENT IMPROVES PROGRESSION FREE SURVIVAL AFTER A FIRST LINE CHEMOTHERAPY IN PATIENTS WITH METASTATIC BREAST CANCER Armelle Dufresne 1 Xavier Pivot 2 Christophe Tournigand3 Thomas Facchini 4 Thierry Alweeg5 Loic Chaigneau 2 Aimery De Gramont 3 1. University Hospital E. Herriot Lyon France 2. University Hospital J. Minjoz Besancon France 3. University Hospital Sain Antoine Paris France 4. Cancer Center Reims France 5. Cancer Center Dijon France Correspondence to Professor Xavier Pivot . . University hospital of J. Minjoz 25000 Besancon France. Received Accepted Published The present study was conducted in patients with metastatic breast cancer. Its aim was to identify the factors which influence progression -free survival PFS and overall survival OS after the first line of chemotherapy in patients with positive tumour hormone receptor status. The patients with early disease progression during first-line chemotherapy were not included. In total 560 patients who achieved a stable disease or a response to first-line chemotherapy were studied. The factors identified to improve the duration of PFS or OS in multivariate analysis were number of metastatic sites p .01 p .01 metastatic sites p .02 p .04 Disease free interval p .001 p .0001 previous hormonal therapy p .03 p ns response to first line chemotherapy p .0001 p and an administration of maintenance hormonal therapy p .0001 p .001 . The major impact obtained by maintenance hormonal treatment after first-line chemotherapy in this study seems to indicate that this strategy should be recommended in patients with an ER or PgR positive tumour. Key words Breast cancer maintenance treatment chemotherapy Metastatic hormonotherapy. INTRODUCTION

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