TAILIEUCHUNG - Báo cáo hóa học: " Measles viral load may reflect SSPE disease progression"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Measles viral load may reflect SSPE disease progression | Virology Journal BioMed Central Open Access Measles viral load may reflect SSPE disease progression M Kuhne Simmonds DWG Brown and L Jin Address Virus Reference Department Centre for Infections Health Protection Agency 61 Colindale Avenue London NW9 5HT UK Email M Kuhne Simmonds - DWG Brown - L Jin - Corresponding author Published 21 June 2006 Received 14 January 2006 Accepted 21 June 2006 Virology Journal 2006 3 49 doi l743-422X-3-49 p This article is available from http content 3 1 49 2006 Simmonds M et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Subacute sclerosing panencephalitis SSPE is a rare slowly progressive neurological disorder caused by the persistent infection with measles virus MV . Despite much research into SSPE its pathology remains obscure. We examined autopsy tissues of eight SSPE patients by real time quantitative PCR immunohistochemistry and immunoblotting to determine viral load. MV N M and H gene RNA could be detected in the central nervous system CNS of all patients and in two non-CNS tissues of one patient. The viral burden between patients differed up to four-fold by quantitative PCR and corresponded with detection of MV protein. The level of both viral RNA and antigen in the brain may correlate with disease progression. Background Subacute sclerosing panencephalitis SSPE is a rare slowly progressive neurological disorder of children and young adults caused by the persistent infection with measles virus MV . After acute infection with MV typically at a very young age the patients appear to recover normally. Following a period of asymptomatic persistence usually 3 to 10 years neural .

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