TAILIEUCHUNG - Báo cáo hóa học: " Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag | Virology Journal BioMed Central Research Open Access Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag Rajeshwari R Valiathan2 and Marilyn D Resh 1 Address 1Cell Biology Program Memorial Sloan-Kettering Cancer Center New York USA and Graduate Program in Biochemistry Cell and Molecular Biology Weill Graduate School of Medical Sciences of Cornell University New York USA and 2University of Michigan Life Sciences Institute Ann Arbor USA Email Rajeshwari R Valiathan - rrv@ Marilyn D Resh - m-resh@ Corresponding author Published II February 2008 Received 25 January 2008 Accepted 11 February 2008 Virology Journal 2008 5 23 doi 1743-422X-5-23 This article is available from http content 5 1 23 2008 Valiathan and Resh licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The ESCRT endosomal sorting complex required for transport machinery functions to sort cellular receptors into the lumen of the multivesicular body MVB prior to lysosomal degradation. ESCRT components can also be recruited by enveloped viruses to sites of viral assembly where they have been proposed to mediate viral egress. For example HIV-1 budding is dependent on Gag-mediated recruitment of the cellular ESCRTs-I -III AIP1 Alix and Vps4 proteins. Viral recruitment of ESCRT proteins could therefore impact on host cell processes such as receptor downregulation. Results Here we show that downregulation of the HIV-1 co-receptor CXCR4 by its ligand SDF- 1 is ESCRT-I dependent. Expression of HIV-1 Gag attenuated downregulation of CXCR4 resulting in accumulation of undegraded receptors within intracellular compartments. The effect of Gag was dependent on an ESCRT-I interacting motif within the .

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