TAILIEUCHUNG - Báo cáo hóa học: " Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression | Virology Journal BioMed Central Research Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression Jaya Rajaiyaf Jingnan Xiaof Raju VS Rajala and James Chodosh Open Access Address Molecular Pathogenesis of Eye Infection Research Center Dean A. McGee Eye Institute Department of Ophthalmology University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA Email Jaya Rajaiya - jayabarathy-rajaiya@ Jingnan Xiao - jingnanxiao@ Raju VS Rajala - raju-rajala@ James Chodosh - james-chodosh@ Corresponding author tEqual contributors Published 25 January 2008 Received 9 December 2007 Accepted 25 January 2008 Virology Journal 2008 5 17 doi l 743-422X-5-17 This article is available from http content 5 1 17 2008 Rajaiya et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human adenovirus type 19 HAdV-19 is a major cause of epidemic keratoconjunctivitis the only ocular adenoviral infection associated with prolonged corneal inflammation. In this study we investigated the role of p38 mitogen-activated protein kinase MAPK in HAdV-19 infection with particular attention to the role of p38 MAPK in the transcriptional control of interleukin-8 IL-8 a chemokine previously shown to be central to the initiation of adenovirus keratitis. Results We found that infection of corneal cells with HAdV-19 led to activation of p38 MAPK and its downstream targets HSP-27 and ATF-2 within 15 to 30 minutes post-infection. Infection also induced phosphorylation of IkB and NFkB in a p38 MAPK-dependent fashion. Furthermore HAdV-19 induced an interaction between p38 MAPK and NFkB-p65 followed by nuclear translocation of activated .

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