TAILIEUCHUNG - Báo cáo y học: " Comparison of side effects of oxytetracycline and talc pleurodesis: an experimental study."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Comparison of side effects of oxytetracycline and talc pleurodesis: an experimental study. | Gozubuyuk et al. Journal of Cardiothoracic Surgery 2010 5 128 http content 5 1 128 JOTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Comparison of side effects of oxytetracycline and talc pleurodesis an experimental study 1 2 3 1 1 1 Alper Gozubuyuk Berkant Ozpolat Ali Fuat Ọpek Hasan Ọaylak Orhan Yucel Kuthan Kavakli Sedat Gurkok1 Onur Genp1 Abstract Background Chemical pleurodesis is widely recommended in the treatment of refractory pleural effusion or pulmonary air leak of different etiologies. Although several agents have been used many questions have remained unanswered about their toxicity. Talc is the most commonly used agent for the treatment with rare serious complications reported. Oxytetracycline pleurodesis in clinical practice has been described in a few studies but literature reveals no experimental studies using this agent. We performed a prospective randomized observer-blinded controlled study to evaluate the changes in lung histology and systemic response to pleurodesis with oxytetracycline and talc in acute and subacute phases in a rat model. Methods Forty-two male albino Wistar rats were divided into three groups and 3 subgroups with 7 animals in each. Group 1 was given oxytetracycline 35 mg kg Group 2 was given talc slurry 60 mg kg in mL saline solution and Group 3 was given only mL saline intrapleurally. In subgroups a the nimls were sacrificed at the postoperative 72nd hour and in subgroups b on the postoperative day 7. The surfaces were graded by microscopic examination. Results Oxytetracycline produced alveolar collapse hemorrhage edema inflammation at the postoperative 72nd hour and hemorrhage on the postoperative day 7 while talc produced significant edema inflammation proliferation fibrosis at the postoperative 72nd hour and hemorrhage edema inflammation proliferation and fibrosis on the postoperative day 7 p 0 0042 . Talc produced significant edema compared to oxytetracycline on the

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