TAILIEUCHUNG - Báo cáo y học: "Effects of inosine on reperfusion injury after cardiopulmonary bypass"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of inosine on reperfusion injury after cardiopulmonary bypass. | Veres et al. Journal of Cardiothoracic Surgery 2010 5 106 http content 5 1 106 JOTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Effects of inosine on reperfusion injury after cardiopulmonary bypass 13 4 2 1 1 Gábor Veres Tamás Radovits Leila Seres Ferenc Horkay Matthias Karck Gábor Szabo Abstract Objective Inosine a break-down product of adenosine has been recently shown to exert inodilatory and antiinflammatory properties. Furthermore inosine might be a key substrate of pharmacological post-conditioning. In the present pre-clinical study we investigated the effects of inosine on cardiac function during reperfusion in an experimental model of cardioplegic arrest and extracorporal circulation. Methods Twelve anesthetized dogs underwent hypothermic cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest reperfusion was started after application of either saline vehicle control n 6 or inosine 100 mg kg n 6 . Left ventricular end-systolic pressure volume relationship ESPVR was measured by a combined pressure-volume-conductance catheter at baseline and after 60 minutes of reperfusion. Left anterior descendent coronary blood flow CBF endothelium-dependent vasodilatation to acetylcholine ACh and endothelium-independent vasodilatation to sodium nitroprusside SNP were also determined. Results The administration of inosine led to a significantly better recovery given as percent of baseline of ESPVR 90 9 vs. 46 6 p . CBF and was also significantly higher in the inosine group 56 8 vs. 23 4 ml min p . While the vasodilatatory response to SNP was similar in both groups ACh resulted in a significantly higher increase in CBF 58 6 vs. 25 5 p in the inosine group. Conclusions Application of inosine improves myocardial and endothelial function after cardiopulmonary bypass with hypothermic cardiac arrest. Background Ischemia-reperfusion injury is a well-known phenomenon after cardiac surgery. Independent

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