TAILIEUCHUNG - NEUROVASCULAR MEDICINE - Pursuing Cellular Longevity for Healthy Aging Part 3

Tuổi già của sinh vật thường kèm theo biểu hiện giảm khả năng chống chọi với stress, mất dần cân bằng nội mội và tăng nguy cơ mắc bệnh tật. Do đó, cái chết là một kết cục cuối cùng của lão hóa. | 108 PATHWAYS OF CLINICAL FUNCTION AND DISABILITY explains the CNS-peripheral cascade which provokes this type of stress Jacobs Heym Trulson 1981 . Prolongation of this behavior triggers the progressive inhibition of the A6 NA neurons because both adrenalin and serotonin are coreleased at this nucleus from axons arising from the C1 Ad and the DR 5-HT nuclei respectively. In addition adrenalin released from the C1 Ad axons limits and or inhibits the A5 NA neurons responsible for neural sympathetic activity by acting at a-2 postsynaptic receptors located at the somatodendritic area of these neurons Li Wesselingh Blessing 1992 Lechin van der Dijs Benaim 1996a Fenik Marchenko Janssen et al. 2002 . Parasympathetic Predominance The uncoping stress disorder is caused by two alternating periods 1 adrenal sympathetic predominance and 2 parasympathetic predominance. Neural sympathetic drive is absent in both circumstances. Raised adrenalin and plasma serotonin f5-HT underlie both alternating periods. The raised f5-HT depends on the maximal serotonin release from the enterochromaffin cells excited by the enhanced parasympathetic drive. In addition the raised levels of plasma adrenalin observed during this uncoping stress s yndrome triggers platelet aggregation. Serotonin arising from platelets is split to the plasma. Carcinoid Syndrome Carcinoid syndrome should be included among the uncoping stress disorders. Both adrenal sympathetic hyperactivity and raised cortisol plasma levels are observed in these patients Lechin van der Dijs Orozco et al. 2005c . Noradrenaline plasma level does not rise at the 1-minute orthostasis challenge and in addition the adrenalin plasma levels show maximal increases through the exercise challenge. The facts that both f5-HT and platelet serotonin p5-HT reach maximal levels during relapsing periods indicate overactivation of both the enterochromaffin cells and the adrenal gland. These cells are submitted to two opposite neurological stimuli .

Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.