TAILIEUCHUNG - báo cáo hóa học: " Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production | Viegas et al. Journal of Occupational Medicine and Toxicology 2010 5 25 http content 5 1 25 JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY RESEARCH Open Access Genotoxic effects in occupational exposure to formaldehyde A study in anatomy and pathology laboratories and formaldehyde-resins production Cl I I Ỉ z-i r- 1 3 LT1 I s II 2 3 M-1 I Z I-3 I z -y ft I I s x r 4 IV ỉ z f f _ r m f r 5 IV ỉ I I IZ I Dritzt4 Susana viegas carina Ladeira Carla Nunes Joana Maita-vacas Mario Gomes Miguel Brito Paula Mendonga2 João Prista6 Abstract Background According to the Report on Carcinogens formaldehyde ranks 25th in the overall . chemical production with more than 5 million tons produced each year. Given its economic importance and widespread use many people are exposed to formaldehyde environmentally and or occupationally. Presently the International Agency for Research on Cancer classifies formaldehyde as carcinogenic to humans Group 1 based on sufficient evidence in humans and in experimental animals. Manyfold in vitro studies clearly indicated that formaldehyde can induce genotoxic effects in proliferating cultured mammalian cells. Furthermore some in vivo studies have found changes in epithelial cells and in peripheral blood lymphocytes related to formaldehyde exposure. Methods A study was carried out in Portugal using 80 workers occupationally exposed to formaldehyde vapours 30 workers from formaldehyde and formaldehyde-based resins production factory and 50 from 10 pathology and anatomy laboratories. A control group of 85 non-exposed subjects was considered. Exposure assessment was performed by applying simultaneously two techniques of air monitoring NIOSH Method 2541 and Photo Ionization Detection equipment with simultaneously video recording. Evaluation of genotoxic effects was performed by application of micronucleus test in exfoliated epithelial cells from buccal mucosa and peripheral blood lymphocytes. Results Time-weighted average .

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