TAILIEUCHUNG - Báo cáo y học: "NPAS2 and PER2 are linked to risk factors of the metabolic syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. | Journal of Circadian Rhythms BioMed Central Open Access NPAS2 and PER2 are linked to risk factors of the metabolic syndrome Ani Englund f1 Leena Kovanent1 Sirkku T Saarikoski1 Jari Haukka1 3 Antti Reunanen2 Arpo Aromaa2 Jouko Lonnqvist1 and Timo Partonen1 Address Department of Mental Health and Alcohol Research National Public Health Institute Mannerheimintie 166 FI-00300 Helsinki Finland 2Department of Health and Functional Capacity National Public Health Institute Mannerheimintie 166 FI-00300 Helsinki Finland and 3Department of Biostatistics and Epidemiology Cluster International Agency for Research on Cancer Lyon France Haukka Email Ani Englund - Leena Kovanen - Sirkku T Saarikoski - Jari Haukka - Antti Reunanen - Arpo Aromaa - Jouko Lonnqvist - Timo Partonen - Corresponding author tEqual contributors Published 26 May 2009 Received 2 February 2009 Journal of Circadian Rhythms 2009 7 5 doi 1740-3391-7-5 Accepted 26 May 2009 This article is available from http content 7 1 5 2009 Englund et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Mammalian circadian clocks control multiple physiological events. The principal circadian clock generates seasonal variations in behavior as well. Seasonality elevates the risk for metabolic syndrome and evidence suggests that disruption of the clockwork can lead to alterations in metabolism. Our aim was to analyze whether circadian clock polymorphisms contribute to seasonal variations in behavior and to the metabolic syndrome. Methods We genotyped 39 single-nucleotide

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