TAILIEUCHUNG - báo cáo hóa học: " Involvement of β-chemokines in the development of inflammatory demyelination"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Involvement of β-chemokines in the development of inflammatory demyelination | Journal of Neuroinflammation BioMed Central Review Open Access Involvement of p-chemokines in the development of inflammatory demyelination Ileana Banisor1 Thomas P Leist2 and Bernadette Kalman 1 Address 1SLRHC Columbia University New York NY USA and 2Thomas Jefferson University Philadephia PA USA Email Ileana Banisor - ileanabc@ Thomas P Leist - Bernadette Kalman - bkalman@ Corresponding author Published 24 February 2005 Received 13 January 2005 Journal ofNeuroinflammation 2005 2 7 doi 1742-2094-2-7 Accepted 24 February 2005 This article is available from http content 2 1 7 2005 Banisor et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The importance of p-chemokines or CC chemokine ligands - CCL in the development of inflammatory lesions in the central nervous system of patients with multiple sclerosis and rodents with experimental allergic encephalomyelitis is strongly supported by descriptive studies and experimental models. Our recent genetic scans in families identified haplotypes in the genes of CCL2 CCL3 and CCL11-CCL8-CCL13 which showed association with multiple sclerosis. Complementing the genetic associations we also detected a distinct regional expression regulation for CCL2 CCL7 and CCL8 in correlation with chronic inflammation in multiple sclerosis brains. These observations are in consensus with previous studies and add new data to support the involvement of CCL2 CCL7 CCL8 and CCL3 in the development of inflammatory demyelination. Along with our own data here we review the literature implicating CCLs and their receptors CCRs in multiple sclerosis and experimental allergic encephalomyelitis. The survey reflects that .

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