TAILIEUCHUNG - Anticoagulation in the Elderly

In general, libraries play an important role in how the elderly seek information. Information literacy efforts on the part of public libraries may help the elderly to learn to become more comfortable with the Internet. If they come to view the Internet as an information-seeking tool, they may become more proactive in their medical decision-making. It remains to be seen how libraries will play a future role in teaching information literacy to the elderly so they can make the most of Internet health resources. To accommodate the manner in which seniors currently seek information, my pathfinder focuses primarily on. | Pharmaceuticals 2010 3 3543-3569 doi ph3123543 OPEN ACCESS pharmaceuticals ISSN 1424-8247 journal pharmaceuticals Review Anticoagulation in the Elderly Helia Robert-Ebadi and Marc Righini Division of Angiology and Hemostasis Department of Internal Medicine Geneva University Hospital and Faculty of Medicine 4 rue Gabrielle Perret-Gentil CH-1211 Geneva 14 Switzerland E-Mail . Author to whom correspondence should be addressed E-Mail Tel. 41-22-372-92-92 Fax 41-22-372-92-99. Received 7 October 2010 in revisedform 7 December 2010 Accepted 9 December 2010 Published 10 December 2010 Abstract Management of anticoagulation in elderly patients represents a particularly challenging issue. Indeed this patient population is at high thromboembolic risk but also at high hemorrhagic risk. Assessment of the benefit-risk balance of anticoagulation is the key point when decisions are made about introducing and or continuing such treatments in the individual elderly patient. In order to maximise the safety of anticoagulation in the elderly some specific considerations need to be taken into account including renal insufficiency modified pharmacodynamics of anticoagulants especially vitamin K antagonists and the presence of multiple comorbidities and concomitant medications. New anticoagulants could greatly simplify and possibly increase the safety of anticoagulation in the elderly in the near future. Keywords anticoagulation elderly patient vitamin K antagonist hemorrhagic risk factor-Xa inhibitor thrombin inhibitors 1. Introduction The prevalence of medical conditions at risk for venous or arterial thrombosis increases gradually with age. Elderly patients are therefore more likely to require anticoagulation therapy at some point either on a short or a long term basis. The most frequently encountered indications for anticoagulation in this category of patients are atrial fibrillation AF with a prevalence of .

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