TAILIEUCHUNG - IMMUNE RESPONSE TO INFLUENZA VACCINATION IN A LARGE HEALTHY ELDERLY POPULATION

In 1999, our department was the first in the nation to establish a clinic dedicated to oral care for the elderly and other people requiring care. In that time we have developed an oral care system to provide effective oral care for the elderly and other people requiring care, which is easy on both them and their families, and an oral care support instrument for elderly requiring a high level of care. Using these methods and instruments, we have attempted to raise the QOL of both the dependent elderly and their caregivers, and improve the general health condition. | PERGAMON Vaccine 17 1999 82-94 Immune response to influenza vaccination in a large healthy elderly population E. Bernstein3 D. Kayea E. Abrutyna p. Gross 3 M. Dorfmana . Muraskoa lMCP Hahnemann School of Medicine Allegheny University of the Health Sciences Philadelphia USA Hackensack Medical Center Hackensack USA Received 30 December 1997 received in revised form 4 March 1998 accepted 4 March 1998 Abstract Elderly individuals not only demonstrate a greater risk of morbidity and mortality from influenza than the young but also have greater difficulty mounting a protective response to influenza vaccine. The mechanism of the decreased efficacy of influenza vaccination in the elderly is not well understood. The present study was designed to assess the interaction between cell-mediated and humoral immune responses to influenza vaccine in a large population n 233 of healthy elderly individuals mean age living in six continuing care retirement communities CCRCs . While influenza vaccination resulted in significant increases in the mean anti-influenza antibody titres and mean proliferative responses of peripheral blood mononuclear cells to purified subvirion trivalent influenza vaccine one month after vaccination only and of subjects had intact humoral and cell-mediated immune responses respectively. No association was observed between intact cell-mediated and humoral responses of subjects had an intact cell-mediated but not humoral response and of subjects had an intact humoral but not cell-mediated response. However IFNy production was significantly correlated with both antibody and cell-mediated responses to influenza vaccination a finding not previously reported in the elderly. These results indicate that there is considerable heterogeneity among immune responses of the elderly to influenza vaccination. This heterogeneity needs to be a major consideration in evaluation of new vaccine preparations. 1998 Elsevier Science Ltd. All rights .

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