TAILIEUCHUNG - báo cáo hóa học: " Morphine stimulates CCL2 production by human neurons"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Morphine stimulates CCL2 production by human neurons | Journal of Neuroinflammation BioMed Central Open Access Morphine stimulates CCL2 production by human neurons R Bryan Rock 1 2 Shuxian Hu1 Wen S Sheng1 and Phillip K Peterson1 Address 1Center for Infectious Diseases and Microbiology Translational Research and the Department of Medicine University of Minnesota Medical School Minneapolis MN USA and 2Division of Infectious Diseases and International Medicine Department of Medicine University of Minnesota Medical School McGuire Translational Research Facility 2001 6th Street SE 3-218 Minneapolis MN 55455 USA Email R Bryan Rock - rockx012@ Shuxian Hu - huxxx031@ Wen S Sheng - sheng008@ Phillip K Peterson - peter137@ Corresponding author Published 08 December 2006 Received 12 October 2006 Accepted 08 December 2006 Journal of Neuroinflammation 2006 3 32 doi l742-2094-3-32 This article is available from http content 3 1 32 2006 Rock et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Substances of abuse such as opiates have a variety of immunomodulatory properties that may influence both neuroinflammatory and neurodegenerative disease processes. The chemokine CCL2 which plays a pivotal role in the recruitment of inflammatory cells in the nervous system is one of only a few chemokines produced by neurons. We hypothesized that morphine may alter expression of CCL2 by human neurons. Methods Primary neuronal cell cultures and highly purified astrocyte and microglial cell cultures were prepared from human fetal brain tissue. Cell cultures were treated with morphine and cells were examined by RNase protection assay for mRNA. .

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