TAILIEUCHUNG - Cancer Medicine 5_2

Tham khảo sách 'cancer medicine 5_2', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Section 27 Neoplasms of the Head and Neck 86 head and neck cancer Gary L. Clayman MD Scott M. Lippman MD George E. Laramore MD Waun Ki Hong MD The American Cancer Society ACS predicted that in 1999 approximately 40 400 new cases of head and neck cancer would be diagnosed in the United States 29 800 with oral cavity and pharyngeal cancer and 10 600 with laryngeal cancer . The same grim reckoning projected 12 300 American deaths in 1999 from this class of These diagnosis and mortality figures correspond to over 4 of all new cancer cases and 2 of all cancer deaths in the United States annually. Nearly identical percentages are reported from Britain but head and neck cancers have a much greater impact in certain other parts of the world and are among the leading causes of cancer mortality 3 Despite improvements in diagnosis and local management long-term survival rates in head and neck cancer have not increased significantly over the past 30 years and are among the lowest worldwide of the major cancers. For African Americans survival rates have decreased. Oropharyngeal cancer the largest subgroup of head and neck cancers has a 5-year relative survival rate of only 55 for United States Caucasians and 32 for African Although early-stage head and neck cancers especially laryngeal and oral cavity have high cure rates over 60 of head and neck cancer patients present with advanced disease. Cure rates decrease of course in locally advanced cases whose probability of cure is inversely related to tumor size and even more so to the extent of regional node involvement. Treatment advances have been undermined by the significant percentage of patients initially cured of head and neck squamous cell carcinoma HNSCC who go on to develop second primary 6 Second primaries are the major threat to long-term survival after successful therapy of early-stage HNSCC. Their high incidence probably results from the same carcinogenic exposure .

• Y học thường thức
• Tumor Suppressor
• Biochemistry of Cancer
• Tumor Angiogenesis
• Cervical Neoplasia
• Hepatitis Viruses
• Cancer Epidemiology
• BMC Cancer
• Prostate cancer
• Suppressor of cytokine signaling 1
• Micro RNA mediated repression
• FUSE binding protein
• Hepatocellular carcinoma
• Tumor suppressor protein p53
• Tumor development
• DNA methylation
• Tumor suppressor genes
• Breast cancer
• Field cancerization
• Tumor adjacent tissue
• Tumor distant tissue
• Methylation sensitive high resolution melting
• Tumor suppressor HIC1
• Interleukin 6
• Cancer associated fibroblasts
• Scientific reports
• scientific research
• biochemistry
• The tumor suppressor p16 INK4a has functions beyond cell cycle control via cyclin dependent kinases
• A coordinated remodeling ofN and O glycosyla tion
• and an increase in the presentation of the endogenous lectin galectin 1 sensing these changes on the surface of p16 INK4a expressing pancreatic carcinoma cells (Capan 1)
• lead to potent pro anoikis signals
• retinoblastoma
• hormone medicine
• Bone marrow derived mesenchymal stem cells
• Long term expansion
• Stem cell aging
• Abundant source
• Tumor suppressor gene
• Tumor suppressor genes plays
• Acute myeloid leukemia
• RAS MAPK pathway
• Tumor suppressor candidate 3
• Esophageal squamous cell carcinoma
• Overall survival
• Esophageal cancer
• Human malignancies
• Endometrial cancer
• Connexin 43
• Adhesion GPCRs
• Vault RNA
• Non coding RNA transcript
• Hippo pathway
• Hippo tumor suppressor pathway
• YAP mediates
• Breast tumors
• Dlc1 gene encodes
• RhoA activity
• Cell cycle
• G1 arrest
• CDKN1A upregulation
• Possible biological
• Long non coding RNA
• Gastric carcinoma
• Epithelial to mesenchymal transition
• RNA binding proteins
• Human cancer
• BMC Bioinformatics
• Cyclin dependent kinase
• Molecular modeling
• CDK2 consensus sequence
• Metastasis tumor suppressor
• Gene expression
• Human prostate cell lines
• EP4 receptor
• Stem like cells
• Polysome profiling
• Lung adenocarcinoma
• Non small cell lung cancer
• Poor prognosis
• Ovarian tumor proteases
• Matrix metalloproteinases
• Cell invasion
• Tumor enhancing gene
• Expectation maximization
• Tumor grade
• Colorectal cancer
• Tumor microenvironment
• Potential biomarkers
• Several cancers