TAILIEUCHUNG - Daptomycin for Treatment of Complicated Skin and Skin Structure Infections

The program has reached providers in over 33 states through train-the-trainer sessions and conferences. Much of the information provided in this report was gained or substantiated through extensive interaction with providers around the United States and internationally. Ultimately through a large evaluation component, impact of the training on preparedness, creation of plans, and staff will be reported. This paper examines the need for LTC comprehensive disaster planning, major considerations, and the exercises that must follow if a LTC community is to be adequately prepared for the disasters they might face. Both physical and mental health realities must be taken into account. | Healthy Aging Clinical Care in the Elderly REVIEW OPEN ACCESS Full open access to this and thousands of other papers at http . Daptomycin for Treatment of Complicated Skin and Skin Structure Infections Maximillian Jahng1 and Jennifer Le2 Department of Pharmacy New Mexico Veterans Affairs VA Healthcare System Albuquerque New Mexico USA. 2Associate Professor of Clinical Pharmacy UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences California USA. Corresponding author email Abstract Acute bacterial skin and skin structure infections ABSSSI are common in the elderly and are often complicated due to several factors including higher prevalence of methicillin-resistant Staphylococcus aureus MRSA and presence of comorbidities compared to younger patients. Daptomycin a cyclic lipopeptide exhibits excellent in vitro bactericidal activity against MRSA and other Gram-positive bacteria associated with complicated skin and skin structure infections cSSSI . Daptomycin achieves adequate drug penetration into inflamed soft tissues and is primarily cleared by the kidneys. Typical daptomycin dosing for cSSSI is 4 mg kg using actual body weight. While some data are available for the safety and efficacy of doses up 12 mg kg higher doses should be reserved for serious and invasive infections. In comparative studies daptomycin was non-inferior to comparator drugs including vancomycin or penicillinase-resistant penicillins for treatment of cSSSI. The overall response rate for daptomycin was greater than 80 . Post-marketing analyses of daptomycin therapy for cSSSI have shown similar clinical success of greater than 80 even in older patients. Daptomycin was generally well-tolerated. The most common side effects were constipation nausea and headaches. The incidences of muscle toxicity were similar between daptomycin and comparator antibiotics less than 5 . However the risk of skeletal muscle toxicity may increase when higher doses of daptomycin .

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