TAILIEUCHUNG - Báo cáo y học: "HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms. | AIDS Research and Therapy BioMed Central Open Access Review HIV-associated adipose redistribution syndrome HARS etiology and pathophysiological mechanisms Kenneth Lichtenstein1 Ashok Balasubramanyam2 Rajagopal Sekhar2 and Eric Freedland 3 Address University of Colorado Infectious Disease Group Practice Denver CO USA 2Division of Diabetes Endocrinology Metabolism Baylor College of Medicine Houston TX USA and 3EMD Serono Inc. Rockland MA USA Email Kenneth Lichtenstein - Ashok Balasubramanyam - ashokb@ Rajagopal Sekhar - rsekhar@ Eric Freedland - Corresponding author Published 27 June 2007 Received 28 March 2007 AIDS Research and Therapy 2007 4 14 doi 1742-6405-4-14 Accepted 27 June 2007 This article is available from http content 4 1 14 2007 Lichtenstein et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Human immunodeficiency virus HIV -associated adipose redistribution syndrome HARS is a fat accumulation disorder characterized by increases in visceral adipose tissue. Patients with HARS may also present with excess truncal fat and accumulation of dorsocervical fat buffalo hump . The pathophysiology of HARS appears multifactorial and is not fully understood at present. Key pathophysiological influences include adipocyte dysfunction and an excessive free fatty acid release by adipocyte lipolysis. The contributory roles of free fatty acids cytokines hormones including cortisol insulin and the growth hormone-adipocyte axis are significant. Other potential humoral paracrine endocrine and neural influences are also discussed. Background Active antiretroviral therapy has reduced mortality of AIDS acquired .

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