TAILIEUCHUNG - Báo cáo y học: "Patterns of neural differentiation in melanomas"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Patterns of neural differentiation in melanomas | Iyengar and Singh Journal of Biomedical Science 2010 17 87 http content 17 1 87 BIN sc The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan JOURNAL OF BIOMEDICAL SCIENCE RESEARCH Open Access Patterns of neural differentiation in melanomas Bhanu Iyengar Avantika V Singh Abstract Background Melanomas highly malignant tumors arise from the melanocytes which originate as multipotent neural crest cells during neural tube genesis. The purpose of this study is to assess the pattern of neural differentiation in relation to angiogenesis in VGP melanomas using the tumor as a three dimensional system. Methods Tumor-vascular complexes TVC are formed at the tumor-stroma interphase by tumor cells ensheathing angiogenic vessels to proliferate into a mantle of 5 to 6 layers L1 to L5 forming a perivascular mantle zone PMZ . The pattern of neural differentiation is assessed by immunopositivity for HMB45 GFAP NFP and synaptophysin has been compared in a the general tumor b tumor-vascular complexes and c perimantle zone PC on serial frozen and paraffin sections. Statistical Analysis ANOVA Kruskal-Wallis One Way Analysis of Variance All Pairwise Multiple Comparison Procedures Tukey Test . Results The cells abutting on the basement membrane acquire GFAP positivity and extend processes. New layers of tumor cells show a transition between L2 to L3 followed by NFP and Syn positivity in L4 L5. The level of GFAP vity in L1 L2 directly proportionate to the percentage of NFP Syn vity in L4 L5 on comparing pigmented PMZ with poorly pigmented PMZ. Tumor cells in the perimantle zone show high NFP 65 and Syn positivity with very low GFAP correlating with the positivity in the outer layers. Discussion From this study it is seen that melanoma cells revert to the embryonic pattern of differentiation with radial glial like cells GFAP ve which further differentiate into neuronal positive cells NFP Syn ve during angiogenic .

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.