TAILIEUCHUNG - Báo cáo y học: " Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose | Abraham et al. Journal of Biomedical Science 2010 17 78 http content 17 1 78 The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan JOURNAL OF BIOMEDICAL SCIENCE RESEARCH Open Access Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress neuroprotective role of pyridoxine and Aegle marmelose Pretty Mary Abraham Korah P Kuruvilla Jobin Mathew Anitha Malat Shilpa Joy CS Paulose Abstract Diabetes and stress stimulate hippocampal 5-HT synthesis metabolism and release. The present study was carried out to find the effects of insulin Aegle marmelose alone and in combination with pyridoxine on the hippocampal 5-HT 5-HT2A receptor subtype gene expression studies on 5-HT2A 5-HTT INSR immunohistochemical studies and elevated plus maze in streptozotocin induced diabetic rats. 5-HT content showed a significant decrease p and a significant increase p in 5-HIAA in hippocampus of diabetic rats compared to control. 5-HT receptor binding parameters Bmax and Kd showed a significant decrease p whereas 5-HT2A receptor binding parameters Bmax showed a significant decrease p with a significant increase p in Kd in hippocampus of diabetic rats compared to control. Gene expression studies of 5-HT2A 5-HTT and INSR in hippocampus showed a significant down regulation p in diabetic rats compared to control. Pyridoxine treated in combination with insulin and A. marmelose to diabetic rats reversed the 5-HT content Bmax Kd of 5-HT 5-HT2A and gene expression of 5-HT2A 5-HTT and INSR in hippocampus to near control. The gene expression of 5-HT2A and 5-HTT were confirmed by immunohistochemical studies. Behavioural studies using elevated plus maze showed that serotonin through its transporter significantly increased p anxiety-related traits in diabetic rats which were corrected by combination therapy. Our results suggest that

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