TAILIEUCHUNG - Chapter 098. Iron Deficiency and Other Hypoproliferative Anemias (Part 6)

Table 98-3 Iron Store Measurements Iron Stores 4+ Marrow Iron Stain, 0– µg/L Serum Ferritin, 0 0 150 Iron overload — 500–1000 Red Cell Protoporphyrin Levels Protoporphyrin is an intermediate in the pathway to heme synthesis. Under conditions in which heme synthesis is impaired, protoporphyrin accumulates within the red cell. | Chapter 098. Iron Deficiency and Other Hypoproliferative Anemias Part 6 Table 98-3 Iron Store Measurements Iron Stores Marrow Iron Stain 0- Serum Ferritin 4 Pg L 0 0 15 1-300 mg Trace to 1 15-30 300-800 mg 2 30-60 mg 800-1000 3 60-150 1-2 g 4 150 Iron overload 500-1000 Red Cell Protoporphyrin Levels Protoporphyrin is an intermediate in the pathway to heme synthesis. Under conditions in which heme synthesis is impaired protoporphyrin accumulates within the red cell. This reflects an inadequate iron supply to erythroid precursors to support hemoglobin synthesis. Normal values are 30 pg dL of red cells. In iron deficiency values in excess of 100 pg dL are seen. The most common causes of increased red cell protoporphyrin levels are absolute or relative iron deficiency and lead poisoning. Serum Levels of Transferrin Receptor Protein Because erythroid cells have the highest numbers of transferrin receptors on their surface of any cell in the body and because transferrin receptor protein TRP is released by cells into the circulation serum levels of TRP reflect the total erythroid marrow mass. Another condition in which TRP levels are elevated is absolute iron deficiency. Normal values are 4-9 pg L determined by immunoassay. This laboratory test is becoming increasingly available and along with the serum ferritin has been proposed to distinguish between iron deficiency and the anemia of chronic inflammation see below . Differential Diagnosis Other than iron deficiency only three conditions need to be considered in the differential diagnosis of a hypochromic microcytic anemia Table 98-4 . The first is an inherited defect in globin chain synthesis the thalassemias. These are differentiated from iron deficiency most readily by serum iron values normal or increased serum iron levels and transferrin saturation are characteristic of the thalassemias. Table 98-4 Diagnosis of Microcytic Anemia Tests Iron Deficiency Inflamma tion Thalasse mia Siderobl astic Anemia Smear Micro h .

• Y học thường thức
• Iron Deficiency
• Hypoproliferative Anemias
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine
• Arachis hypogaea
• Iron uptake gene
• Fe deficiency
• Pakistani peanut varieties
• BMC Pediatrics
• Iron deficiency anemia
• Red cell distribution width
• Operating characteristic curve
• Iron supplementation
• Iron deficiency anaemia
• Sub Saharan Africa
• Plant Biology
• Hydrogen sulphide
• Iron assimilation
• Organic acid
• Plant hormones
• Early childhood caries
• Preschool child
• BMC Pulmonary Medicine
• Renal failure
• Chronic obstructive pulmonary disease
• Oxygen therapy
• Chronic kidney disease
• Anemia of chronic disease
• Dietary iron
• Iron therapy
• Cultivated strawberry
• Genetic resources
• Tissue culture
• Genotypes against iron deficiency
• Fruit tree crops
• Undigested gum found during colonoscopy
• Undigested gum
• Unexplained iron deficiency anemia
• Colonoscopy were planned
• Sweet corn
• Agronomic fortification
• Agronomic fortification with zinc
• Iron to enhancing micronutrient concentration
• Sweet corn grain
• Ameliorate the deficiency symptoms
• Human beings
• Dealing with zinc
• Iron deficiency in rice
• Combine strategies to fight hidden hunger
• Fight hidden hunger
• Developing countries
• Febrile seizures
• Nutritional deficiencies
• Multivariate logistic regression analysis
• Blood lymphocyte subsets
• CD8+ T lymphocytes
• CD19+ B lymphocytes
• Rapunzel syndrome
• Abdominal pain
• Case report