TAILIEUCHUNG - Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 3)

Radiation Marrow aplasia is a major acute sequela of radiation. Radiation damages DNA; tissues dependent on active mitosis are particularly susceptible. Nuclear accidents can involve not only power plant workers but also employees of hospitals, laboratories, and industry (food sterilization, metal radiography, etc.), as well as innocents exposed to stolen, misplaced, or misused sources. While the radiation dose can be approximated from the rate and degree of decline in blood counts, dosimetry by reconstruction of the exposure can help to estimate the patient's prognosis and also to protect medical personnel from contact with radioactive tissue and excreta. MDS and. | Chapter 102. Aplastic Anemia Myelodysplasia and Related Bone Marrow Failure Syndromes Part 3 Radiation Marrow aplasia is a major acute sequela of radiation. Radiation damages DNA tissues dependent on active mitosis are particularly susceptible. Nuclear accidents can involve not only power plant workers but also employees of hospitals laboratories and industry food sterilization metal radiography etc. as well as innocents exposed to stolen misplaced or misused sources. While the radiation dose can be approximated from the rate and degree of decline in blood counts dosimetry by reconstruction of the exposure can help to estimate the patient s prognosis and also to protect medical personnel from contact with radioactive tissue and excreta. MDS and leukemia but probably not aplastic anemia are late effects of radiation. Chemicals Benzene is a notorious cause of bone marrow failure. Vast quantities of epidemiologic clinical and laboratory data link benzene to aplastic anemia acute leukemia and blood and marrow abnormalities. The occurrence of leukemia is roughly correlated with cumulative exposure but susceptibility must also be important as only a minority of even heavily exposed workers develop benzene myelotoxicity. The employment history is important especially in industries where benzene is used for a secondary purpose usually as a solvent. Benzene-related blood diseases have declined with regulation of industrial exposure. Although benzene is no longer generally available as a household solvent exposure to its metabolites occurs in the normal diet and in the environment. The association between marrow failure and other chemicals is much less well substantiated. Drugs Table 102-3 Many chemotherapeutic drugs have marrow suppression as a major toxicity effects are dose-dependent and will occur in all recipients. In contrast idiosyncratic reactions to a large and diverse group of drugs may lead to aplastic anemia without a clear dose-response relationship. These .

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• Aplastic Anemia
• Myelodysplasia
• Related Bone Marrow Failure Syndromes
• tài liệu học ngành y
• Harrisons Internal Medicine
• Severe aplastic anemia
• Hematopoietic stem cell transplantation
• Conditioning regimen
• Iron overload
• Matched sibling donor
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• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• medical books
• pharmacology
• epidemiologic
• Obstetrics
• anatomy
• Preventing Morbidity
• Multidisciplinary Care