TAILIEUCHUNG - Physics in Nuclear Medicine Second Edition

Reliable gene-lifestyle interaction studies will yield important evidence for the shaping of personalised healthcare. Studies need statistical power with adequate environmental exposures and lifestyle heterogeneity to obtain reliable evidence on the interplay between nurture and nature. Europe has a historic strength in large epidemiological studies but technology development and implementation is needed to better ascertain environmental exposure and dietary heterogeneity. There is a lack of information about the quality and quantity of biological samples of existing European cohorts and about the completeness and consistency of phenotype data. This type of information is required. | Physics in Nuclear Medicine Second Edition James A. Sorenson . Director Medical Physics Professor of Radiology Department of Radiology University of Utah Medical Center Salt Lake City Utah Michael E. Phelps . Jennifer Jones Simon Professor Chief Division of Nuclear Medicine and Biophysics Department of Radiological Sciences UCLA School of Medicine Chief Laboratory of Nuclear Medicine Laboratory of Biomedical and Environmental Sciences UCLA Los Angeles California . SAUNDERS COMPANY Harcourt Brace Jovanovich Inc. Philadelphia London Toronto Montreal Sydney Tokyo 16 The Anger Camera Performance Characteristics B. DESIGN AND PERFORMANCE CHARACTERISTICS OF PARALLEL-HOLE COLLIMATORS 1. Basic Limitations in Collimator Performance The collimator is a weak link for the performance of an Anger camera system as indeed it is in any nuclear medicine imaging system employing the principles of absorptive collimation. Collimator efficiency defined as the fraction of y rays striking the collimator that actually pass through it to project the y-ray image onto the detector is typically only a few percent or less. Collimator resolution which refers to the sharpness or detail of the y-ray image projected onto the detector also is rather poor generally worse than the intrinsic resolution of the camera detector and electronics. Because it is a limiting factor in camera system performance it is important that the collimator be designed carefully. Poor design can result only in poorer overall performance. Design considerations for parallelhole collimators will be discussed in this section. Design characteristics for converging and diverging collimators are similar to those of the parallel-hole type. Design characteristics of pinhole collimators will not be discussed in detail here but are described in references listed at the end of the chapter. The analysis to be presented for parallel-hole collimators 332 Physics in Nuclear Medicine is similar to that presented by Anger in .

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