TAILIEUCHUNG - Báo cáo khoa học: Biologically active, non membrane-anchored precursors – an overview

Peptides function as chemical signals between cells of multicellular organ-isms via specific receptors on target cells. Many hormones, neuromodula-tors and growth factors are peptides. Peptide hormones and other biologically active peptides are synthesized as higher molecular weight pre-cursor proteins (pro-hormones), which must undergo post-translational modification to yield the bioactive peptide(s). | iFEBS Journal REVIEW ARTICLE Biologically active non membrane-anchored precursors -an overview Eleni Dicou Institut de Pharmacologie Moleculaire et Cellulaire du CNRS UMR6097 Valbonne France Keywords bioactive precursors chromogranins precerebellin proapoA-I proCHR proenkephalin progastrin proGRP proneurotrophins PTH-P Correspondence E. Dicou Department of Biochemistry and Molecular Biology University of Texas MedicalBranch Galveston TX 77555-1072 USA Fax 1 409 772 8028 Tel 1 409 772 3686 E-mail Received 27 November 2007 revised 15 February 2008 accepted 28 February 2008 doi Peptides function as chemical signals between cells of multicellular organisms via specific receptors on target cells. Many hormones neuromodulators and growth factors are peptides. Peptide hormones and other biologically active peptides are synthesized as higher molecular weight precursor proteins pro-hormones which must undergo post-translational modification to yield the bioactive peptide s . In many instances more than one biologically active peptide is generated from one and the same precursor. In most cases these precursors are biologically inert and their existence is confined to the membrane-enclosed subcellular compartments where processing of the pro-hormones takes place. A class of growth factors that derive from membrane-anchored precursors which themselves are biologically active constitute an exception to this model. The list of the membrane-anchored biologically active precursors has been the subject of specialized reviews. The present review focuses on precursors other than membrane-anchored precursors which were found to be biologically active and which often display different biological activities and may mediate their effects via receptors independent from those of their generated peptides. Introduction Precursor proteins mature through proteolytic cleavage within the cell. In most cases these precursors are biologically .

• Báo cáo khoa học
• Report medicine
• traditional medicine
• scientific reports
• biochemical studies
• environmental medicine
• Crystal structure
• medical knowledge
• medical research
• analysis of cytoplasmic
• oxidation
• bacteria
• hemoglobin
• medicine
• cell proliferation
• breast cancer
• chemical reaction
• gastric cancer
• hormone medicine
• tumor cells