TAILIEUCHUNG - Báo cáo khoa học: A unique tetrameric structure of deer plasma haptoglobin – an evolutionary advantage in the Hp 2-2 phenotype with homogeneous structure

Similar to blood types, human plasma haptoglobin (Hp) is classified into three phenotypes: Hp 1-1, 2-1 and 2-2. They are genetically inherited from two alleles Hp 1and Hp 2(represented in bold), but only the Hp 1-1 phenotype is found in almost all animal species. | ỊFEBS Journal A unique tetrameric structure of deer plasma haptoglobin -an evolutionary advantage in the Hp 2-2 phenotype with homogeneous structure I. H. Lai1 Kung-Yu Lin1 Mikael Larsson2 Ming Chi Yang1 Chuen-Huei Shiau3 Ming-Huei Liao4 and Simon J. T. Mao1 5 1 Institute of BiochemicalEngineering College of BiologicalScience and Technology NationalChiao Tung University Hsinchu Taiwan 2 Department of Chemicaland BiologicalEngineering Chalmers University of Technology Gothenburg Sweden 3 Pingtung County Livestock Disease ControlCenter Pingtung Taiwan 4 Department of Veterinary Medicine NationalPingtung University of Science and Technology Pingtung Taiwan 5 Department of Biotechnology and Bioinformatics Asia University Taichung Taiwan Keywords amino acid sequence deer and human haptoglobin monoclonalantibody phenotype purification Correspondence S. J. T. Mao Institute of Biochemical Engineering College of Biological Science and Technology NationalChiao Tung University 75 Po-Ai Street Hsinchu 30050 Taiwan Fax 886 3 572 9288 Tel 886 3 571 2121 ext. 56948 E-mail mao1010@ Database The sequence corresponding to deer Hp is available in the DDBJ EMBL GenBank database under the accession number EF601928 Received 21 November 2007 revised 20 December 2007 accepted 28 December 2007 doi Similar to blood types human plasma haptoglobin Hp is classified into three phenotypes Hp 1-1 2-1 and 2-2. They are genetically inherited from two alleles Hp 1 and Hp 2 represented in bold but only the Hp 1-1 phenotype is found in almost all animal species. The Hp 2-2 protein consists of complicated large polymers cross-linked by a2-p subunits or a2-P n where n 3 up to 12 or more and is associated with the risk of the development of diabetic cardiovascular and inflammatory diseases. In the present study we found that deer plasma Hp mimics human Hp 2 containing a tandem repeat over the a-chain based on our cloned cDNA sequence. Interestingly the .

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