TAILIEUCHUNG - Chapter 104. Acute and Chronic Myeloid Leukemia (Part 12)

Clinical Presentation Symptoms The clinical onset of the chronic phase is generally insidious. Accordingly, some patients are diagnosed while still asymptomatic, during health-screening tests; other patients present with fatigue, malaise, and weight loss or have symptoms resulting from splenic enlargement, such as early satiety and left upper quadrant pain or mass. Less common are features related to granulocyte or platelet dysfunction, such as infections, thrombosis, or bleeding. Occasionally, patients present with leukostatic manifestations due to severe leukocytosis or thrombosis such as vasoocclusive disease, cerebrovascular accidents, myocardial infarction, venous thrombosis, priapism, visual disturbances, and pulmonary insufficiency. Patients with p230BCR/ABL-positive CML have a. | Chapter 104. Acute and Chronic Myeloid Leukemia Part 12 Clinical Presentation Symptoms The clinical onset of the chronic phase is generally insidious. Accordingly some patients are diagnosed while still asymptomatic during health-screening tests other patients present with fatigue malaise and weight loss or have symptoms resulting from splenic enlargement such as early satiety and left upper quadrant pain or mass. Less common are features related to granulocyte or platelet dysfunction such as infections thrombosis or bleeding. Occasionally patients present with leukostatic manifestations due to severe leukocytosis or thrombosis such as vasoocclusive disease cerebrovascular accidents myocardial infarction venous thrombosis priapism visual disturbances and pulmonary insufficiency. Patients with p230BCR ABL-positive CML have a more indolent course. Progression of CML is associated with worsening symptoms. Unexplained fever significant weight loss increasing dose requirement of the drugs controlling the disease bone and joint pain bleeding thrombosis and infections suggest transformation into accelerated or blastic phases. Fewer than 10-15 of newly diagnosed patients present with accelerated disease or with de novo blastic phase CML. Physical Findings Minimal to moderate splenomegaly is the most common physical finding mild hepatomegaly is found occasionally. Persistent splenomegaly despite continued therapy is a sign of disease acceleration. Lymphadenopathy and myeloid sarcomas are unusual except late in the course of the disease when they are present the prognosis is poor. Hematologic Findings Elevated white blood cell counts WBCs with increases in both immature and mature granulocytes are present at diagnosis. Usually 5 circulating blasts and 10 blasts and promyelocytes are noted with the majority of cells being myelocytes metamyelocytes and band forms. Cycling of the counts may be observed in patients followed without treatment. Platelet counts are almost always .

• Y học thường thức
• Acute and Chronic Myeloid Leukemia
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine
• Chronic myeloid leukemia
• Acute myeloid leukemia
• Imatinib mesylate
• Leukemia markers
• Anti leukemia drugs in myeloid leukemia
• BMC Cancer
• Acute lymphoblastic leukemia
• Chronic lymphocytic leukemia
• Case rep
• Chemotherapeutic agents
• Phase I
• Myelodysplastic syndrome
• Chronic myelomonocytic leukemia
• Acute lympho leukemia
• Hyperleukocytic symptoms
• Clinical symptoms of leukostatsis
• Pathology competencies
• Organ system pathology
• Myeloid neoplasia
• Myelodysplastic syndromes
• Myeloproliferative neoplasms
• Tobacco smoking
• Including chronic myeloid leukemia
• Tyrosine kinase inhibitor
• Hematopoietic stem cell transplantation
• Kinase inhibitors
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo