TAILIEUCHUNG - Chapter 104. Acute and Chronic Myeloid Leukemia (Part 11)

Chronic Myelogenous Leukemia Incidence The incidence of chronic myelogenous leukemia (CML) is per 100,000 people per year, and the age-adjusted incidence is higher in men than in women ( versus ). The incidence of CML increases slowly with age until the middle forties, when it starts to rise rapidly. CML incidence for males decreased slightly () between 1997 and 2003 as compared to 1977–1997. Definition The diagnosis of CML is established by identifying a clonal expansion of a hematopoietic stem cell possessing a reciprocal translocation between chromosomes 9 and 22. This translocation results in the head-to-tail fusion of the breakpoint cluster region. | Chapter 104. Acute and Chronic Myeloid Leukemia Part 11 Chronic Myelogenous Leukemia Incidence The incidence of chronic myelogenous leukemia CML is per 100 000 people per year and the age-adjusted incidence is higher in men than in women versus . The incidence of CML increases slowly with age until the middle forties when it starts to rise rapidly. CML incidence for males decreased slightly between 1997 and 2003 as compared to 1977-1997. Definition The diagnosis of CML is established by identifying a clonal expansion of a hematopoietic stem cell possessing a reciprocal translocation between chromosomes 9 and 22. This translocation results in the head-to-tail fusion of the breakpoint cluster region BCR gene on chromosome 22q11 with the ABL named after the abelson murine leukemia virus gene located on chromosome 9q34. Untreated the disease is characterized by the inevitable transition from a chronic phase to an accelerated phase and on to blast crisis in a median time of 4 years. Etiology No clear correlation with exposure to cytotoxic drugs has been found and no evidence suggests a viral etiology. In the pre-imatinib era cigarette smoking accelerated the progression to blast crisis and therefore adversely affected survival in CML. Atomic bomb survivors had an increased incidence the development of a CML cell mass of 10 000 pL took years. No increase in CML incidence was found in the survivors of the Chernobyl accident suggesting that only large doses of radiation can induce CML. Pathophysiology The product of the fusion gene resulting from the t 9 22 plays a central role in the development of CML. This chimeric gene is transcribed into a hybrid BCR ABL mRNA in which exon 1 of ABL is replaced by variable numbers of 5 BCR exons. Bcr Abl fusion proteins p210BCR ABL are produced that contain NH2-terminal domains of Bcr and the COOH-terminal domains of Abl. A rare breakpoint occurring within the 3 region of the BCR gene yields a fusion protein of 230

• Y học thường thức
• Acute and Chronic Myeloid Leukemia
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine
• Chronic myeloid leukemia
• Acute myeloid leukemia
• Imatinib mesylate
• Leukemia markers
• Anti leukemia drugs in myeloid leukemia
• BMC Cancer
• Acute lymphoblastic leukemia
• Chronic lymphocytic leukemia
• Case rep
• Chemotherapeutic agents
• Phase I
• Myelodysplastic syndrome
• Chronic myelomonocytic leukemia
• Acute lympho leukemia
• Hyperleukocytic symptoms
• Clinical symptoms of leukostatsis
• Pathology competencies
• Organ system pathology
• Myeloid neoplasia
• Myelodysplastic syndromes
• Myeloproliferative neoplasms
• Tobacco smoking
• Including chronic myeloid leukemia
• Tyrosine kinase inhibitor
• Hematopoietic stem cell transplantation
• Kinase inhibitors
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• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo