TAILIEUCHUNG - Báo cáo khoa học: "Distribution of caveolin isoforms in the lemur retina"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Distribution of caveolin isoforms in the lemur retina | J. Vet. Set. 2007 8 3 295-297 JOURNAL OF Short Communication Veterinary Science Distribution of caveolin isoforms in the lemur retina Ágnes I Berta Anna L Kiss Ákos Lukáts Arnold Szabo Ágoston Szél Department of Human Morphology and Developmental Biology Faculty of Medicine Semmehveis University Budapest 1094 Hungary The distribution of caveolin isoforms was previously evaluated in the retinas of different species but has not yet been described in the primate retina. In this study the distribution of caveolins was assessed via immunochemistry using isoform-specific antibodies in the retina of the black-and-white ruffed lemur. Here we report the presence of a variety of caveolin isoforms in many layers of the lemur retina. As normal human retinas were not available for research and the retinas of primates are fairly similar to those of humans the lemur retina can be utilized as a model for caveolin distribution in normal humans. Key words caveolin immunocytochemistry lemur retina Caveolins are integral membrane proteins which are principal components of the omega-shaped plasma membrane invaginations referred to as caveolae. Multiple forms of caveolin have been identified thus far and have been designated caveolin-1 caveolin-2 and caveolin-3. These variants differ with regard to specific properties and tissue distribution. Caveolin-1 and caveolin-2 may originate from a common ancestor and are expressed most abundantly in adipocytes endothelial cells fibroblasts and smooth muscle cells 7 . They have also been identified in neuronal cells 2 Caveolin-3 expression was previously believed to be muscle-specific 7 although it has been shown to be present in astroglial cells 6 and neurons of the vegetative ganglions as well 5 . Scherer et al. 8 also previously identified two caveolin isofonns within Caenorhabditis elegans demonstrating that caveolins are both structurally and functionally conserved across species from worms to humans. These data indicate that caveolins may .

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