TAILIEUCHUNG - The Diesel Exhaust in Miners Study: A Nested Case–Control Study of Lung Cancer and Diesel Exhaust

Telch and Telch (1986) randomized 41 cancer patients with different diagnoses and stages of disease to a coping skills instruction group, an emotional support group or a no-treatment control group. The coping skills group showed consistent improvement in affective state, cognitive distress, communications, coping with medical procedures, and satisfaction related to work, social activities, physical appearance, sexual inti- macy, physical and social activities. Patients in the emotional support group showed little or no improvement, while the control patients actually deteriorated in psychological functioning. In a similar study, Cunningham and Tocco (1989), randomly assigned 60 cancer patients with mixed diagnoses to one of two group treatments: a support group which included. | DOI jnci djs034 JNCI djs034 HA JOURNAL NAME Art. No. CE Code Published by Oxford University Press 2012. ARTICLE 5 10 15 20 25 30 35 40 45 The Diesel Exhaust in Miners Study A Nested Case-Control Study of Lung Cancer and Diesel Exhaust Debra T. Silverman Claudine M. Samanic Jay H. Lubin Aaron E. Blair Patricia A. Stewart Roel Vermeulen Joseph B. Coble Nathaniel Rothman Patricia L. Schleiff William D. Travis Regina G. Ziegler Sholom Wacholder Michael D. Attfield Manuscript received February 16 2011 revised June 3 2011 accepted October 21 2011. Correspondence to Debra T. Silverman ScD Occupational and Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Rm 8108 6120 Executive Blvd Bethesda MD 20816 e-mail silvermd@ . Background Most studies of the association between diesel exhaust exposure and lung cancer suggest a modest but consistent increased risk. However to our knowledge no study to date has had quantitative data on historical diesel exposure coupled with adequate sample size to evaluate the exposure-response relationship between diesel exhaust and lung cancer. Our purpose was to evaluate the relationship between quantitative estimates of exposure to diesel exhaust and lung cancer mortality after adjustment for smoking and other potential confounders. Methods We conducted a nested case-control study in a cohort of 12 315 workers in eight non-metal mining facilities which included 198 lung cancer deaths and 562 incidence density-sampled control subjects. For each case subject we selected up to four control subjects individually matched on mining facility sex race ethnicity and birth year within 5 years from all workers who were alive before the day the case subject died. We estimated diesel exhaust exposure represented by respirable elemental carbon REC by job and year for each subject based on an extensive retrospective exposure assessment at each mining facility. We conducted both .

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