TAILIEUCHUNG - Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer

Although the psychosocial oncology literature is strong, substantial limitations and unanswered questions remain. Much of the research has focused on heterogeneous samples of patients who vary widely across disease site (., melanoma vs. breast cancer), stage of progression (., localized vs. metastatic), and phase of illness (., initial diagnosis vs. long-term survival). The challenges patients face vary widely across these dimensions, and therefore, it is crucial for research designs to take this into consideration | INTERNATIONAL JOURNAL OF ONCOLOGY 23 975-982 2003 Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes A novel treatment for human brain cancer SEN PATHAK1 2 ASHA S. MULTANI1 PRATIP BANERJI3 and PRASANTA BANERJI3 Departments of 1Cancer Biology and 2Laboratory Medicine The University of Texas . Anderson Cancer Center Houston TX 77030 USA 3PBH Research Foundation 10 3 1 Elgin Road Kolkata 700 020 West Bengal India Received April 16 2003 Accepted May 28 2003 Abstract. Although conventional chemotherapies are used to treat patients with malignancies damage to normal cells is problematic. Blood-forming bone marrow cells are the most adversely affected. It is therefore necessary to find alternative agents that can kill cancer cells but have minimal effects on normal cells. We investigated the brain cancer cell-killing activity of a homeopathic medicine Ruta isolated from a plant Ruta graveolens. We treated human brain cancer and HL-60 leukemia cells normal B-lymphoid cells and murine melanoma cells in vitro with different concentrations of Ruta in combination with Ca3 PO4 2. Fifteen patients diagnosed with intracranial tumors were treated with Ruta 6 and Ca3 PO4 2. Of these 15 patients 6 of the 7 glioma patients showed complete regression of tumors. Normal human blood lymphocytes B-lymphoid cells and brain cancer cells treated with Ruta in vitro were examined for telomere dynamics mitotic catastrophe and apoptosis to understand the possible mechanism of cell-killing using conventional and molecular cytogenetic techniques. Both in vivo and in vitro results showed induction of survival-signaling pathways in normal lymphocytes and induction of death-signaling pathways in brain cancer cells. Cancer cell death was initiated by telomere erosion and completed through mitotic catastrophe events. We propose that Ruta in combination with Ca3 PO4 2 could be used for effective treatment of brain cancers particularly

• Y học thường thức
• race ethnicity based
• substantial proportion
• global environmental
• inefficient resource
• society organizations
• Environment and Development
• BMC Geriatrics
• Health differences
• Mental health
• Physical health
• Log binomial regression
• Dialogue and Understanding
• Development Environment
• mapping Business Process Models
• Information State Update dialogue systems
• scientific reports
• model language
• process natural language
• Evaluation criteria completion
• Road traffic construction
• Term of environment according to sustainable development
• Towards sustainable development
• Sustainable development in construction
• Computer based learning environment
• Support diagnostic problem solving
• Towards expertise development
• Problem solving
• Medical education
• Problem based learning
• Economics aspect
• Environmental aspect
• Sustainable agriculture development
• Environment aspects in Vietnam
• Economics and environment aspects
• Socio economic environment
• Academic giftedness of Russian students
• Social and economic environment
• Academic giftedness of Russian schoolchildren
• Development of Russian education
• Ultural environment
• Cultural environment in Vietnam
• Psychosphere for development
• The majority of population
• Happiness index
• RAD Studio
• Mobile Tutorials
• Mobile application development
• Development Environment on the Mac (iOS)
• Development Environment on Windows PC (iOS)
• FireMonkey mobile application
• Web browser component
• Business system development
• Information systems
• Information systems analysis
• Application software
• Systems development
• Systems Development Life Cycle
• Economic development
• Lecture International economic development
• International economic development
• Kinh tế phát triển
• Economic growth
• Nuclear engineering and technology
• Development of simulation based testing environment
• Safety critical software
• Simulation based testing environment
• The plant dynamics
• Digital Instrumentation and Control System
• Software Reliability Quantification
• Continuous learning work environment
• A study with developers
• Software development organizations
• Continuous learning
• Work environment
• Sustainable tourism development
• The southern central Vietnam
• Environment protection
• Socio economic development
• Environmental protection
• Communist Party
• Sustainable development
• Environment pollute
• Serious environment crisis
• Human capital
• Agricultural transformation
• Rural development
• The environment and development
• Civil society
• International trade theory
• The environment
• Development policymaking
• multiple
• county
• species
• habitat
• plan
• conservation
• riverside
• western
• development
• environment
• costs
• revenues
• benefits
• balancing
• something
• dynamic
• army
• old
• new
• leader
• A Best Practices Guided
• Information Extraction
• báo cáo khoa học
• báo cáo ngôn ngữ
• ngôn ngữ tự nhiên
• The Summarization Integrated
• Moonyoung Kang
• xử lý ngôn ngữ tự nhiên
• Rafeeq Ur Rehman; Christopher Paul
• The Linux Development
• Programming Environment
• Linux Systems
• Broadband technology and services
• Environment influencing national broadband development
• Lrge scale network investment
• Qualitative research method
• Evidence based approach
• Digital goverment
• Environment management
• Simultaneously mobilize
• Contribute quickly
• Industrial wastewater
• Human behavior and the social environment
• Group as a social system
• Social system
• Community development
• Organizational environment
• Family in society