TAILIEUCHUNG - Chapter 120. Osteomyelitis (Part 1)

Harrison's Internal Medicine Chapter 120. Osteomyelitis Osteomyelitis: Introduction Osteomyelitis, an infection of bone, is caused most commonly by pyogenic bacteria and mycobacteria. As a useful framework for evaluating a patient and planning treatment, cases are classified on the basis of the causative agent; the route by which organisms gain access to bone; the duration of infection; the anatomic location of infection; and the local and systemic host factors that have a bearing on pathogenesis and outcome. Pathogenesis and Pathology Microorganisms enter bone by hematogenous dissemination, by spread from a contiguous focus of infection, or by a penetrating wound. Trauma, ischemia, and foreign. | Chapter 120. Osteomyelitis Part 1 Harrison s Internal Medicine Chapter 120. Osteomyelitis Osteomyelitis Introduction Osteomyelitis an infection of bone is caused most commonly by pyogenic bacteria and mycobacteria. As a useful framework for evaluating a patient and planning treatment cases are classified on the basis of the causative agent the route by which organisms gain access to bone the duration of infection the anatomic location of infection and the local and systemic host factors that have a bearing on pathogenesis and outcome. Pathogenesis and Pathology Microorganisms enter bone by hematogenous dissemination by spread from a contiguous focus of infection or by a penetrating wound. Trauma ischemia and foreign bodies enhance the susceptibility of bone to microbial invasion by exposing sites to which bacteria can bind and by impeding host defenses. Phagocytes attempt to contain the infection and in the process release enzymes that lyse bone. Bacteria escape host defenses by adhering tightly to damaged bone by entering and persisting within osteoblasts and by coating themselves and underlying surfaces with a protective polysaccharide-rich biofilm. Pus spreads into vascular channels raising intraosseous pressure and impairing the flow of blood as the untreated infection becomes chronic ischemic necrosis of bone results in the separation of large devascularized fragments sequestra . When pus breaks through the cortex subperiosteal or soft tissue abscesses form and the elevated periosteum deposits new bone an involucrum around the sequestrum. Microorganisms infiltrates of neutrophils and congested or thrombosed blood vessels are the principal histologic findings of acute osteomyelitis. The distinguishing feature of chronic osteomyelitis is necrotic bone which is characterized by the absence of living osteocytes. Mononuclear cells predominate in chronic infections and granulation and fibrous tissues replace bone that has been resorbed by osteoclasts. In the chronic

• Y học thường thức
• Osteomyelitis
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine
• Musculoskeletal melioidosis
• Burkholderia pseudomallei osteomyelitis
• Chronic osteomyelitis
• Malaysian return driver
• Skull Osteomyelitis
• Chronic Non Bacterial
• Osteitis Chronic Recurrent
• Multifocal Osteomyelitis
• Treatment of Osteomyelitis
• Bleeding During Surgery
• BMC Musculoskeletal Disorders
• Calcium sulfate
• Diabetic foot osteomyelitis
• Surgical treatment
• Osteomyelitis recurrence rate
• Induced membrane
• Two stage surgery
• Hematogenous osteomyelitis
• Acute hematogenous osteomyelitis
• Radiofrequency Treatments
• Review and New Approaches
• Etiology and Pathogenesis
• Pathogenesis of Osteomyelitis
• Diagnosis and Types
• BMC Pediatrics
• Inflammatory bowel disease
• Chronic non infectious osteomyelitis
• Ulcerative colitis
• Joint pain
• Staphylococcus aureus
• Antimicrobial susceptibility
• Tertiary care centre
• Post traumatic osteomyelitis
• Bacteriological profile
• Chronic nonbacterial osteomyelitis
• Clavicle reconstruction
• Free peroneal graft
• Typical radiographic findings
• BMC Pulmonary Medicine
• Mycobacterium abscessus ssp abscessus
• Vertebral osteomyelitis
• pulmonary disease
• Non tuberculous mycobacteria
• Chronic recurrent multifocal osteomyelitis
• Periosteal proliferation
• Idiopathic inflammatory disease
• Humeral cortex
• Fibular osteomyelitis
• Distal fibular
• Knee stability
• Disturb ankle kinematics significantly
• Microbiological profile
• Tertiary care hospital
• Poor blood supply
• Diabetic wounds
• Loss of protective sensation
• Mauricio S
• Baptista and João Paulo Tardivo
• Health
• Sciences
• medicine
• pharmacolocy
• Gram positive filamentous organism
• Chronic granulomatous disease
• Cervicofacial actinomycosis
• Actinomycotic osteomyelitis
• Vancomycin calcium sulfate implantation
• Fenestration decompression
• Sclerosing osteomyelitis
• C reactive protein
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• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
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