TAILIEUCHUNG - Pordeus Imm 94 Final

Tham khảo sách 'pordeus imm 94 final', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Current Trends in Immunology Vol. 10 2009 Immunopathology and oligoclonal T cell expansions. Observations in immunodeficiency infections allergy and autoimmune diseases Pa C 1 cP di 7 1 f U dVY AC2 f du 11 d u d w 7d IP d3 A vnk Í n arlae p d z c d TT 1 Tv 4 Vitorpordeus G ustavoc nus ClaudiaR. Carvalho Iichi ncdvd DaibusaDvCastioơi. Andre Pires Da Cunha4 and Nelson M. Vaz4 1Núcleo de Cultura Ciência e Saúde da Secretaria Municipal de Saúde e Defesa Civil Rio de Janeiro 2Departamento de Farmacologia CCB UFSC Florianópolis SC 3Departamento de Morfologia ICB UFMG Belo Horizonte MG 4Departamento de Bioquímica e Imunologia ICB UFMG Belo Horizonte MG Brasil ABSTRACT The immune system is usually seen as a collection of independent specific lymphocyte clones. Randomly generated and activated at random these lymphocytes follow only their individual clonal history. Thus in traditional descriptions immunological activity is neither systemic nor historical and is never physiological . However recent descriptions show an abundant auto -reactivity in healthy organisms an evidence of internal connectivity. The two major sources of immunogenic contacts namely dietary proteins and products of the autochthonous microbiota fail to induce progressive secondary-type clonal expansions or memory . Natural IgM may arise in antigen-free organisms as they do in conventionally raised animals actually clonal receptors of both T and B lymphocytes are formed in antigen-free intracellular environments and are not driven by antigen exposure. Early in ontogenesis natural immunoglobulins are organized in characteristic patterns of reactivity which are robustly stable throughout healthy living Corresponding author Dr. Vitor Pordeus Rua Prof. Antônio Maria Teixeira 33 apto 203 Leblon Rio de Janeiro Brazil 22430050 vitorpordeus@ these patterns depend on genes known to be important in immunological activity. Predictable not-random variations on these patterns occur during infectious and .

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