TAILIEUCHUNG - Population genetic variation in gene expression is associated with phenotypic variation in Saccharomyces cerevisiae
Department of Genome Sciences, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Rd, Berkeley, CA 94720, USA. †Department of Biology, University of Pennsylvania, 324 Leidy Laboratories, Philadelphia, PA 19104, USA. ‡Center for Integrative Genomics, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. §Current address: Department of Genetics, Washington University, 4566 Scott Ave, St. Louis, MO 63110, USA. Correspondence: Justin C Fay. E-mail: jfay@ reviews Published: 24 March 2004 Genome Biology 2004, 5:R26 The electronic version of this article is the complete one and can be found online at. | Research Open Access Population genetic variation in gene expression is associated with phenotypic variation in Saccharomyces cerevisiae Justin C Fay Heather L McCullough Paul D Sniegowski and Michael B Eisen Addresses Department of Genome Sciences Life Sciences Division Lawrence Berkeley National Laboratory One Cyclotron Rd Berkeley CA 94720 USA. Department of Biology University of Pennsylvania 324 Leidy Laboratories Philadelphia PA 19104 USA. Center for Integrative Genomics Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA. Current address Department of Genetics Washington University 4566 Scott Ave St. Louis MO 63110 USA. Correspondence Justin C Fay. E-mail jfay@ Published 24 March 2004 Genome Biology 2004 5 R26 The electronic version of this article is the complete one and can be found online at http 2004 5M R26 Received 28 January 2004 Revised 25 February 2004 Accepted 27 February 2004 2004 Fay et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background The relationship between genetic variation in gene expression and phenotypic variation observable in nature is not well understood. Identifying how many phenotypes are associated with differences in gene expression and how many gene-expression differences are associated with a phenotype is important to understanding the molecular basis and evolution of complex traits. Results We compared levels of gene expression among nine natural isolates of Saccharomyces cerevisiae grown either in the presence or absence of copper sulfate. Of the nine strains two show a reduced growth rate and two others are rust colored in the presence of copper sulfate. We identified 633 genes that show significant differences in expression among strains. Of these genes 20 .
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