TAILIEUCHUNG - Báo cáo khoa học: "Comparative analysis of heart functions in micropigs and conventional pigs using echocardiography and radiography"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Comparative analysis of heart functions in micropigs and conventional pigs using echocardiography and radiography | J. Vet. Sci. 2007 8 1 7-14 JOURNAL OF Veterinary Science Comparative analysis of heart functions in micropigs and conventional pigs using echocardiography and radiography Min Young Lee Sang Hun Lee Seung Gon Lee Soo Hyun Park Chai Yong Lee Kye Hun Kim Sun Ho Hwang2 Sang Yub Lim2 Young Keun Ahn2 Ho Jae Han1 1 College of Veterinary Medicine Biotherapy Human Resources Center BK21 and2Department of Cardiology Chonnam National University Hospital Chonnam National University Gwangju 500-757 Korea The production of miniature animals has been suggested for use in organ transplantation. At present many of the studies about application of animal organs to human have been focused on pigs because of the number of advantages involved and due to their similarities with human. However a physiological analysis of the organs to be transplanted has not yet been carried out. Therefore this study analyzed whether or not there were physiological and morphological differences in the hearts of conventionally-reared pigs and micropigs. In this study the morphological and physiological functions of the heart were examined using radiographic and echocardiographic equipment. In the lateral radiographic view the heart of the micropig has a larger cardiac long axis short axis ratio than does the conventional pig but the difference in the vertebral heart score was not significant. In addition there were no morphological differences on the X-ray fluoroscopic view. There were no differences in echocardiographic values except for several values in the left ventricle traces. Overall it is expected that the values measured in this study will contribute to understanding of the physiological characteristics of micropigs. Key words conventional pig micropig physiological cardiac function Introduction The severe shortage of human donor organs has stimulated interest in the potential use of animal organs for transplantation into humans 6 . Xenotransplantation as such would not only offer an unlimited .

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