TAILIEUCHUNG - Báo cáo khoa hoc:" A sampling algorithm for segregation analysis"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: A sampling algorithm for segregation analysis | 587 Genet Sei. Evol. 33 2001 587-603 INRA EDP Sciences 2001 Original article a sampling algorithm for segregation analYsis Bruce Tier John Henshall Animal Genetics and Breeding Unit UniversitY of New EnGland Armidale NSW 2351 Australia Received 27 June 2000 accepted 12 June 2001 Abstract - Methods for detecting Quantitative Trait Loci QTL without markers have generally used iterative peeling algorithms for determining genotype probabilities. These algorithms have considerable shortcomings in complex pedigrees. A Monte Carlo Markov chain MCMC method which samples the pedigree of the whole population jointly is described. Simultaneous sampling of the pedigree was achieved by sampling descent graphs using the Metropolis-Hastings algorithm. A descent graph describes the inheritance state of each allele and provides pedigrees guaranteed to be consistent with Mendelian sampling. Sampling descent graphs overcomes most if not all of the limitations incurred by iterative peeling algorithms. The algorithm was able to find the QTL in most of the simulated populations. However when the QTL was not modeled or found then its effect was ascribed to the polygenic component. No QTL were detected when they were not simulated. descent graphs Monte Carlo Markov chain quantitative trait loci Metropolis-Hastings 1. introduction Considerable research has been directed at locating quantitative trait loci QTL among continuously distributed traits in the genome of various species using designed experiments and marker information. There is also keen interest in searching for possible QTL in complex pedigree structures without markers in domesticated livestock. This is called segregation analysis in which both the effect of an allele at a postulated QTL and the probabilities that individuals in the population carry 0 1 or 2 copies of the desirable allele are of interest. Methods for segregation analysis have been suggested by a number of authors . 11 13 15 20 . Models that include a QTL .

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