TAILIEUCHUNG - Báo cáo khoa học: " Expression of pituitary adenylate cyclase activating polypeptide and its type I receptor mRNAs in human placenta"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Expression of pituitary adenylate cyclase activating polypeptide and its type I receptor mRNAs in human placenta | J. Vet. Sci. 2005 6 1 1-5 JOURNAL OF Veterinary Science Expression of pituitary adenylate cyclase activating polypeptide and its type I receptor mRNAs in human placenta Phil-Ok Koh1 Chung-Kil Won1 Hae-Sook Noh2 Gyeong-Jae Cho2 Wan-Sung Choi2 1 Department of Anatomy College of Veterinary Medicine and Institute of Animal Medicine Gyeongsang National University Jinju 660-701 Korea Department of Anatomy and Neurobiology College of Medicine Institute of Health Sciences Gyeongsang National University Jinju 660-751 Korea Pituitary adenylate cyclase activating polypeptide PACAP was first isolated from ovine hypothalamus and was known to stimulate the release of growth factor in various cells. Recently we reported the cellular localization of PACAP and its type I PACj receptor in rat placenta during pregnancy. Placenta is a critical organ that synthesizes several growth factors and angiogenic factors for the fetal development and its own growth. However there is little information regarding the cellular localization of PACAP and its receptor in human placenta at various gestations. The aim of the present study was to define the expression and distribution of PACAP and PAC1 receptor mRNAs in the human placenta during the pregnancy period. PACAP and PAC1 receptor mRNAs were expressed in stroma cells of stem villi and terminal villi. At the early stage on 7 and 14 weeks PACAP and PAC1 receptor genes were moderately expressed in stroma cells surrounding the blood vessels within stem villi. These genes were strongly expressed in stroma cells of stem villi and terminal villi on 24 and 38 weeks. The expression of these genes was increased as gestation advanced and localized in the same areas. Localization of PACAP and PAC1 receptor demonstrate the evidence that PACAP may play an important role as an autoregulator or pararegulator via its PAC1 receptor. In conclusion our findings strongly suggest that PACAP may have a critical role in physiological function of the placenta for .

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