TAILIEUCHUNG - Báo cáo khoa học: "Idiopathic canine polyarteritis in control beagle dogs from toxicity studies"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Idiopathic canine polyarteritis in control beagle dogs from toxicity studies | J. Vet. Sci. 2004 5 2 147-150 JOURNAL OF Veterinary Science Idiopathic canine polyarteritis in control beagle dogs from toxicity studies Woo-Chan Son Department of Pathology Huntingdon Life Sciences Woolley Road Alconbury Huntingdon Cambridgeshire PE28 4HS UK It is sometimes difficult to assess the relevance of polyarteritis with treatment-related lesions in dog toxicity studies as number of dogs used in a toxicity study is small and the lesions are similar to those seen in spontaneous diseases. This report is intended to establish a general profile of idiopathic canine polyarteritis in beagle dogs. Data from a total of 40 dog studies including 4- 13- or 52weeks studies conducted between 1990 and 2003 at Huntingdon Life Sciences UK were collected and analysed. There was no death by this disease and also no prominent clinical signs related to this disease. Histologically males tended to develop polyarteritis more frequently than in females and epididymis is the most probable tissues followed by thymus and heart. Dogs in two studies showed higher incidences of these lesions whereas animals in the other studies did not exhibited suggesting that genetic predilection plays an important role in this disease. Key words beagle dog pain polyarteritis Introduction There are some reports on spontaneously occurring polyarteritis in the dog especially beagle dog which were described as beagle pain syndrome 5 idiopathic canine polyarteritis 2 6 spontaneous disseminated panarteritis 8 or spontaneous extramural coronary arteritis 4 . The pathogenesis and incidence were reviewed by several authors 1 2 3 4 5 7 9 10 11 . Most of this disease is spontaneous and their occurrence in beagle dog is relatively common. As this disease often encounters in toxicity study small vascular lesions are often mistaken as treatment-related changes which could be complicated if the treated compounds are expected to show vascular lesions. This report is intended to establish a general profile of .

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